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A novel PTHrP (PTHrP\u20102) that can be used locally to promote osseointegration of macroporous titanium alloy scaffold (mTAS) and counteract implant slippage in osteoporosis patients is designed. In vitro, PTHrP\u20102 enhances the proliferation, adhesion, and osteogenic differentiation of bone marrow\u2010derived mesenchymal stem cells (BMSCs) within the mTAS. Further, it promotes proliferation, migration, angiogenesis\u2010related protein expression, and angiogenesis in human umbilical vein endothelial cells (HUVECs). Compared to PTH(1\u201334), PTHrP\u20102 can partially weaken the osteoclast differentiation of RAW 264.7 cells. Even in an oxidative stress microenvironment, PTHrP\u20102 safeguards the proliferation and migration of BMSCs and HUVECs, reduces reactive oxygen species generation and mitochondrial damage, and partially preserves the angiogenesis of HUVECs. In the Sprague\u2013Dawley (SD) rat osteoporosis model, the therapeutic benefits of PTHrP\u20102\u2010releasing mTAS (mTAS<jats:sup>P2<\/jats:sup>) and ordinary mTAS implanted for 12 weeks via micro\u2010CT, sequential fluorescent labeling, and histology are compared. The results demonstrate that mTAS<jats:sup>P2<\/jats:sup> exhibits high bone growth rate, without osteophyte formation. Consequently, PTHrP\u20102 exhibits unique local synthesis properties and holds the potential for assisting the osseointegration of alloy implants in osteoporosis patients.<\/jats:p>","DOI":"10.1002\/adhm.202301604","type":"journal-article","created":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T12:21:36Z","timestamp":1692188496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["A Novel PTH\u2010Related Peptide Combined With 3D Printed Macroporous Titanium Alloy Scaffold Enhances Osteoporotic Osseointegration"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3553-4390","authenticated-orcid":false,"given":"Junwu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopedics Zhongnan Hospital of Wuhan University  Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renxin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Zhongnan Hospital of Wuhan University  Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Zhongnan Hospital of Wuhan University  Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinyu","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Zhongnan Hospital of Wuhan University  Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beihai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Zhongnan Hospital of Wuhan University  Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuowen","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Zhongnan Hospital of Wuhan University  Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Zhongnan Hospital of Wuhan University  Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingkun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Zhongnan Hospital of Wuhan University  Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Zhongnan Hospital of Wuhan University  Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Zhongnan Hospital of Wuhan University  Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Zhongnan Hospital of Wuhan University  Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai 200233 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2737-972X","authenticated-orcid":false,"given":"Jingfeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Zhongnan Hospital of Wuhan University  Wuhan 430071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32112-3"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.20.00989"},{"key":"e_1_2_8_3_1","first-page":"105","volume":"133","author":"Clynes M. 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