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Various hydrogel barriers have been developed to prevent peritoneal adhesion. However, it remains a challenge to design a hydrogel with desirable physicochemical properties and bioactivities. In this study, a zwitterionic polysaccharide\u2010based multifunctional hydrogel is developed using epigallocatechin\u20103\u2010gallate (EGCG) to prevent postoperative abdominal adhesion. This hydrogel is simple to use and has desirable properties, such as excellent injectability, self\u2010healing, and non\u2010swelling properties. The hydrogel also has ultralow fouling capabilities, such as superior bactericidal performance, cell and protein adhesion, and low immunogenicity resistance. Moreover, the hydrogel exhibits good antioxidant activity, which is attributed to the integration of EGCG. Furthermore, the detailed mechanism from in vivo and in vitro experimental studies illustrates that hydrogel compositions can synergistically prevent adhesion formation through multiple pathways, including anti\u2010inflammatory and antioxidant capabilities and inhibition effects on the mesothelial\u2010mesenchymal transition (MMT) process induced by transforming growth factor (TGF\u2010\u03b2). In summary, this zwitterionic multifunctional hydrogel has great potential to prevent postoperative adhesion formation in the clinical setting.<\/jats:p>","DOI":"10.1002\/adhm.202301696","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T16:00:33Z","timestamp":1693929633000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["A Zwitterionic Hydrogel with Anti\u2010Oxidative and Anti\u2010Inflammatory Properties for the Prevention of Peritoneal Adhesion by Inhibiting Mesothelial\u2010Mesenchymal Transition"],"prefix":"10.1002","volume":"12","author":[{"given":"Qingyu","family":"Yu","sequence":"first","affiliation":[{"name":"Key Laboratory of Systems Bioengineering (Ministry of Education) Department of Polymer Science School of Chemical Engineering and Technology Tianjin University  Tianjin 300072 China"},{"name":"Tianjin Key Laboratory of Biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy Institute of Biomedical Engineering Chinese Academy of Medical Sciences &amp; 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