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To tackle this challenge, an advanced self\u2010powered enzyme\u2010linked microneedle (MN) nerve conduit is designed and fabricated. This innovative conduit is composed of anodic and cathodic MN arrays, which contain glucose oxidase (GOx) and horseradish peroxidase (HRP) encapsulated in ZIF\u20108 nanoparticles, respectively. Through an enzymatic cascade reaction, this MN nerve conduit generates microcurrents that stimulate the regeneration of muscles, blood vessels, and nerve fibers innervated by the sciatic nerve, eventually accelerating the repair of sciatic nerve injury. It is clear that this self\u2010powered MN nerve conduit will revolutionize traditional treatment methods for sciatic nerve injury and find widespread application in the field of nerve tissue repair.<\/jats:p>","DOI":"10.1002\/adhm.202301729","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T12:28:45Z","timestamp":1690979325000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Implantable Nerve Conduit Made of a Self\u2010Powered Microneedle Patch for Sciatic Nerve Repair"],"prefix":"10.1002","volume":"12","author":[{"given":"Xiangli","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing School of Stomatology Lanzhou University  Gansu Province Lanzhou 730000 P. R. 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