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As the transmucosal component of implant, the abutment therefore needs to be biofunctionalized to repair the gingival barrier. Here, a mussel\u2010bioinspired implant abutment coating containing tannic acid (TA), cerium and minocycline (TA\u2010Ce\u2010Mino) is reported. TA provides pyrogallol and catechol groups to promote cell adherence. Besides, Ce\n                    <jats:sup>3+<\/jats:sup>\n                    \/Ce\n                    <jats:sup>4+<\/jats:sup>\n                    \u00a0conversion exhibits enzyme\u2010mimetic activity to remove reactive oxygen species while generating O\n                    <jats:sub>2<\/jats:sub>\n                    , therefore promoting anti\u2010inflammatory M2 macrophage polarization to help create a regenerative environment. Minocycline is\u00a0involved on the TA surface to create local drug storage for responsive\u00a0antibiosis. Moreover, the underlying therapeutic mechanism is revealed whereby the coating exhibits exogenous antioxidation from the inherent properties of Ce and TA and endogenous antioxidation through mitochondrial homeostasis maintenance and antioxidases promotion. In addition, it stimulates integrin to activate PI3K\/Akt and RhoA\/ROCK pathways to enhance VEGF\u2010mediated angiogenesis and tissue regeneration. Combining the antibiosis and multidimensional orchestration, TA\u2010Ce\u2010Mino repairs soft tissue barriers and effector cell differentiation, thereby isolating the immune microenvironment from pathogen invasion. Consequently, this study provides critical insight into the design and biological mechanism of abutment surface modification to prevent peri\u2010implantitis.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202301733","type":"journal-article","created":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T03:19:31Z","timestamp":1693711171000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["A Dual\u2010Antioxidative Coating on Transmucosal Component of Implant to Repair Connective Tissue Barrier for Treatment of Peri\u2010Implantitis"],"prefix":"10.1002","volume":"12","author":[{"given":"Dize","family":"Li","sequence":"first","affiliation":[{"name":"Stomatological Hospital of Chongqing Medical University Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Chongqing Medical University  Chongqing 401147 P. R. 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