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Electrical cues are critical bioactive factors that promote nerve regrowth, and bioartificial scaffolds incorporating conductive materials to enhance the endogenous electrical field have been demonstrated to be effective. The utilization of fully biodegradable scaffolds can eliminate material residues, and circumvent the need for secondary retrieval procedures. Here, a fully bioresorbable and conductive nerve scaffold integrating N\u2010type silicon (Si) membranes is proposed, which can deliver both structural guidance and electrical cues for the repair of nerve defects. The entire scaffold is fully biodegradable, and the introduction of N\u2010type Si can significantly promote the proliferation and production of neurotrophic factors of Schwann cells and enhance the calcium activity of dorsal root ganglion (DRG) neurons. The conductive scaffolds enable accelerated nerve regeneration and motor functional recovery in rodents with sciatic nerve transection injuries. This work sheds light on the advancement of bioresorbable and electrically active materials to achieve desirable neural interfaces and improved therapeutic outcomes, offering essential strategies for regenerative medicine.<\/jats:p>","DOI":"10.1002\/adhm.202301859","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T08:09:35Z","timestamp":1695715775000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["A Bioresorbable and Conductive Scaffold Integrating Silicon Membranes for Peripheral Nerve Regeneration"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3222-8742","authenticated-orcid":false,"given":"Pengcheng","family":"Sun","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering The Key Laboratory of Advanced Materials of Ministry of Education State Key Laboratory of New Ceramics and Fine Processing Center for Flexible Electronics Technology Tsinghua University  Beijing 100084 P. 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