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Effective regulation of the inflammatory microenvironment has important clinical significance for OA alleviation and cartilage protection. Polycitrate\u2010based polymers have good antioxidant and anti\u2010inflammatory abilities but cannot self\u2010polymerize to form hydrogels. Herein, a one\u2010component multifunctional polycitrate\u2010based (PCCGA) hydrogel for OA alleviation and cartilage protection is reported. The PCCGA hydrogel is prepared using only the PCCGA polymer by self\u2010polymerization and exhibits multifunctional properties such as injectability, adhesion, controllable pore size and elasticity, self\u2010healing ability, and photoluminescence. Moreover, the PCCGA hydrogel exhibits good biocompatibility, biodegradability, antioxidation by scavenging intracellular reactive oxygen species, and anti\u2010inflammatory ability by downregulating the expression of proinflammatory cytokines and promoting the proliferation and migration of stem cells. In vivo results from an OA rat model show that the PCCGA hydrogel can effectively alleviate OA and protect the cartilage by restoring uniform articular surface and cartilage ECM levels, as well as inhibiting cartilage resorption and matrix metalloproteinase\u201013 levels. These results indicate that the PCCGA hydrogel, as a novel bioactive material, is an effective strategy for OA treatment and has broad application prospects in inflammation\u2010related biomedicine.<\/jats:p>","DOI":"10.1002\/adhm.202301953","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T15:34:14Z","timestamp":1696347254000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Injectable Bioactive Antioxidative One\u2010Component Polycitrate Hydrogel with Anti\u2010Inflammatory Effects for Osteoarthritis Alleviation and Cartilage Protection"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4574-1411","authenticated-orcid":false,"given":"Min","family":"Wang","sequence":"first","affiliation":[{"name":"Honghui Hospital Xi'an Jiaotong University  Xi'an 710000 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