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Herein, a novel synthetic strategy is reported based on core\u2013shell\u2010structured curcumin\u2010nanocomposite\u2010reinforced ion\u2010conductive hydrogel for synchronous heart electrophysiological signal monitoring and infarcted heart repair. The nanoreinforcement and multisite cross\u2010linking of bioactive curcumin nanoparticles enable well elasticity with negligible hysteresis, implantability, ultrahigh mechanoelectrical sensitivity (37\u00a0ms), and reliable sensing capacity (over 3000 cycles) for the nanoreinforced hydrogel. Results of in vitro and in vivo experiments demonstrate that such solely physical microenvironment of electrophysiological and biomechanical characteristics combining with the role of bioactive curcumin exert the synchronous benefit of regulating inflammatory microenvironment, promoting angiogenesis, and reducing myocardial fibrosis for effective myocardial infarction (MI) repair. Especially, the hydrogel sensors offer the access for achieving accurate acquisition of cardiac signals, thus monitoring the whole MI healing process. This novel bioactive and electrophysiological\u2010sensing ion\u2010conductive hydrogel cardiac patch highlights a versatile strategy promising for synchronous integration of in vivo real\u2010time monitoring the MI status and excellent MI repair performance.<\/jats:p>","DOI":"10.1002\/adhm.202301990","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T18:36:18Z","timestamp":1689791778000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["A Core\u2013Shell Nanoreinforced Ion\u2010Conductive Implantable Hydrogel Bioelectronic Patch with High Sensitivity and Bioactivity for Real\u2010Time Synchronous Heart Monitoring and Repairing"],"prefix":"10.1002","volume":"12","author":[{"given":"Si","family":"Shen","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering School of Basic Medical Science Southern Medical University  Guangzhou Guangdong 510515 P. 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