{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T14:21:22Z","timestamp":1768832482952,"version":"3.49.0"},"reference-count":48,"publisher":"Wiley","issue":"31","license":[{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21804059"],"award-info":[{"award-number":["21804059"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21701059"],"award-info":[{"award-number":["21701059"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20180974"],"award-info":[{"award-number":["BK20180974"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Multimodal cancer therapies show great promise in synergistically enhancing anticancer efficacy through different mechanisms. However, most current multimodal therapies either rely on complex assemblies of multiple functional nanomaterials and drug molecules or involve the use of nanomedicines with poor in vivo degradability\/metabolizability, thus restricting their clinical translatability. Herein, a nanoflower\u2010medicine using iron ions, thioguanine (TG), and tetracarboxylic porphyrin (TCPP) are synthesized as building blocks through a one\u2010step hydrothermal method for combined chemo\/chemodynamic\/photodynamic cancer therapy. The resulting nanoflowers, consisting of low\u2010density Fe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    core and iron complex (Fe\u2010TG and Fe\u2010TCPP compounds) shell, exhibit high accumulation at the tumor site, desirable degradability in the tumor microenvironment (TME), robust suppression of tumor growth and metastasis, as well as effective reinvigoration of host antitumor immunity. Triggered by the low pH in tumor microenvironment, the nanoflowers gradually degrade after internalization, contributing to the effective drug release and initiation of high\u2010efficiency catalytic reactions precisely in tumor sites. Moreover, iron ions can be eliminated from the body through renal clearance after fulfilling their mission. Strikingly, it is also found that the multimodal synergistic therapy effectively elicits the host antitumor immunity without inducing additional toxicity. This easy\u2010manufactured and degradable multimodal therapeutic nanomedicine is promising for clinical precision oncology.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202302016","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T15:58:42Z","timestamp":1694793522000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["One\u2010Pot Synthesis of Tumor\u2010Microenvironment Responsive Degradable Nanoflower\u2010Medicine for Multimodal Cancer Therapy with Reinvigorating Antitumor Immunity"],"prefix":"10.1002","volume":"12","author":[{"given":"Jiamin","family":"Sun","sequence":"first","affiliation":[{"name":"School of Environmental &amp; Chemical Engineering Jiangsu University of Science and Technology  Changhui Rd. 666 Zhenjiang Jiangsu 212003 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Environmental &amp; Chemical Engineering Jiangsu University of Science and Technology  Changhui Rd. 666 Zhenjiang Jiangsu 212003 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Environmental &amp; Chemical Engineering Jiangsu University of Science and Technology  Changhui Rd. 666 Zhenjiang Jiangsu 212003 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqing","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Environmental &amp; Chemical Engineering Jiangsu University of Science and Technology  Changhui Rd. 666 Zhenjiang Jiangsu 212003 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Environmental &amp; Chemical Engineering Jiangsu University of Science and Technology  Changhui Rd. 666 Zhenjiang Jiangsu 212003 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyue","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Environmental &amp; Chemical Engineering Jiangsu University of Science and Technology  Changhui Rd. 666 Zhenjiang Jiangsu 212003 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianzhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Analytical for Life Science School of Chemistry and Chemical Engineering Nanjing University  Xianlin Ave 163 Nanjing Jiangsu 210023 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Xiong","sequence":"additional","affiliation":[{"name":"School of Environmental &amp; Chemical Engineering Jiangsu University of Science and Technology  Changhui Rd. 666 Zhenjiang Jiangsu 212003 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0580-7896","authenticated-orcid":false,"given":"Fenfen","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Environmental &amp; Chemical Engineering Jiangsu University of Science and Technology  Changhui Rd. 666 Zhenjiang Jiangsu 212003 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine  West Huaihai 241 200030 Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8201-1285","authenticated-orcid":false,"given":"Jun\u2010Jie","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Analytical for Life Science School of Chemistry and Chemical Engineering Nanjing University  Xianlin Ave 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