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Therefore, developing models that can better predict the effects of sugar substitutes on the human body is necessary. Here, a new type of endocrine pancreas\u2010on\u2010a\u2010chip is developed based on a microfiber assembly and its stimulation of pancreatic secretion by glucose or sugar substitutes is evaluated. This new endocrine pancreas\u2010on\u2010a\u2010chip is assembled using two components: (1) a cell\u2010loaded hollow methacrylate gelatin (GelMA)\/calcium alginate (CaA) composite microfiber prepared by microfluidic spinning to achieve vascular simulation and material transport, and (2) a 3D pancreatic islet culture layer, which also serves as a fiber assembly microchip. Using this established organ chip, the effects of five sweeteners (glucose, erythritol, xylitol, sodium cyclamate, and sucralose) were investigated on pancreatic islet cell viability and insulin and glucagon secretion. The constructed endocrine pancreas\u2010on\u2010a\u2010chip has potential for the safety evaluation of sugar\u2010substituted food additives, which can expand the application of organ chips in the field of food safety and provide a new platform for evaluating various food additives.<\/jats:p>","DOI":"10.1002\/adhm.202302104","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T21:04:41Z","timestamp":1695762281000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hollow Microfiber Assembly\u2010Based Endocrine Pancreas\u2010on\u2010a\u2010Chip for Sugar Substitute Evaluation"],"prefix":"10.1002","volume":"13","author":[{"given":"Lingling","family":"Tian","sequence":"first","affiliation":[{"name":"Materials Genome Institute Shanghai University  Shanghai 200444 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