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In clinical practice; however, it remains a challenge to achieve a noninvasive and safe treatment. Herein, a biocompatible shell with excellent antioxidant and antivascularity is prepared by co\u2010assembly of epigallocatechin gallate\/gallic acid and Cu (II). After loading glucose oxidase (GO<jats:italic>x<\/jats:italic>) inside, the shell is modified with dimeric DPA\u2010Zn for codelivering vascular endothelial growth factor (VEGF) small interfering RNA (VEGF\u2010siRNA). Meanwhile, the Arg\u2010Gly\u2010Asp peptide (RGD) peptide\u2010engineered cell membranes coating improves angiogenesis\u2010targeting and is biocompatible for the multifunctional nanomedicine (CEGs\/RGD). After eye drops administration, CEGs\/RGD targets enrichment in neovascularization and CEGs NPs enter cells. Then, the inner GO<jats:italic>x<\/jats:italic> consumes glucose with a decrease in local pH, which in turn leads to the release of EGCE and VEGF\u2010siRNA. As a result, the nanomedicines significantly reduce angiogenesis and inhibit CNV formation through synergistic effect of antioxidant and antivascular via down\u2010regulation of cluster of differentiation 31 and VEGF. The nanomedicine represents a safe and efficient CNV treatment through the combined effect of antioxidant\/gene, which provides important theoretical and clinical significance.<\/jats:p>","DOI":"10.1002\/adhm.202302192","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T06:08:30Z","timestamp":1701238110000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["A Synergistic Therapy With Antioxidant and Anti\u2010VEGF: Toward its Safe and Effective Elimination for Corneal Neovascularization"],"prefix":"10.1002","volume":"13","author":[{"given":"Huimin","family":"Zhu","sequence":"first","affiliation":[{"name":"Xiamen University Affiliated Xiamen Eye Center, Eye Institute of Xiamen University School of Medicine Xiamen University  Xiamen 361102 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