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In this work, a novel dental pulp stem cells (DPSCs) encapsulated thermoresponsive injectable hydrogel with sustained hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) delivery is demonstrated for SCI repair. For controlled and sustained H<jats:sub>2<\/jats:sub>S gas therapy, a clinically tested H<jats:sub>2<\/jats:sub>S donor (JK) loaded octysilane functionalized mesoporous silica nanoparticles (OMSNs) are incorporated into the thermosensitive hydrogel made from Pluronic F127 (PF\u2010127). The JK\u2010loaded functionalized MSNs (OMSF@JK) promote preferential M2\u2010like polarization of macrophages and neuronal differentiation of DPSCs in vitro. OMSF@JK incorporated PF\u2010127 injectable hydrogel (PF\u2010OMSF@JK) has a soft consistency similar to that of the human spinal cord and thus, shows a high cytocompatibility with DPSCs. The cross\u2010sectional micromorphology of the hydrogel shows a continuous porous structure. Last, the PF\u2010OMSF@JK composite hydrogel considerably improves the in vivo SCI regeneration in Sprague\u2013Dawley rats through a reduction in inflammation and neuronal differentiation of the incorporated stem cells as confirmed using western blotting and immunohistochemistry. The highly encouraging in vivo results prove that this novel design on hydrogel is a promising therapy for SCI regeneration with the potential for clinical translation.<\/jats:p>","DOI":"10.1002\/adhm.202302286","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T04:28:23Z","timestamp":1701923303000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Local Spinal Cord Injury Treatment Using a Dental Pulp Stem Cell Encapsulated H<sub>2<\/sub>S Releasing Multifunctional Injectable Hydrogel"],"prefix":"10.1002","volume":"13","author":[{"given":"Abdullkhaleg Ali","family":"Albashari","sequence":"first","affiliation":[{"name":"Center of Regenerative Medicine, Department of Stomatology Renmin Hospital of Wuhan University Wuhan Hubei 430060 China"},{"name":"School and Hospital of Stomatology Wenzhou Medical University  Wenzhou Zhejiang 325035 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