{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:16:16Z","timestamp":1790208976616,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"31","license":[{"start":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T00:00:00Z","timestamp":1695427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52003097"],"award-info":[{"award-number":["52003097"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["YCJJ202201003"],"award-info":[{"award-number":["YCJJ202201003"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2020kfyXJJS060"],"award-info":[{"award-number":["2020kfyXJJS060"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2023JYCXJJ052"],"award-info":[{"award-number":["2023JYCXJJ052"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The stratum corneum (SC) and cell membrane are two major barriers that hinder the therapeutic outcomes of transdermal drug delivery for the treatment of skin diseases. While microneedles (MNs) can efficiently penetrate the SC to deliver nanomedicines, the optimization of physicochemical properties of nanomedicines in MNs to enhance their in vivo cellular delivery efficiency remains unclear. Here, how the size and surface charge of drug\u2010loaded liposomes in MNs influence the retention time and cellular delivery in psoriatic skin is systematically investigated. The results indicate that while 100\u00a0nm negatively\u2010charged liposomes in MNs show higher cellular uptake in vitro, 250 and 450\u00a0nm liposomes could enhance skin retention and the long\u2010term in vivo cellular delivery efficiency of drugs. Moreover, 250\u00a0nm cationic liposomes with a stronger positive charge show an extraordinarily long skin retention time of 132\u00a0h and significantly higher in vivo cellular internalization. In the treatment study, dexamethasone (dex)\u2010loaded cationic liposomes\u2010integrated MNs show better therapeutic outcomes than dex\u2010loaded anionic liposomes\u2010integrated MNs in a psoriasis\u2010like animal model. The design principles of liposomes in MN drug delivery systems explored in the study hold the potential for enhancing the therapeutic outcomes of psoriasis and are instrumental for successful translation.<\/jats:p>","DOI":"10.1002\/adhm.202302314","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T19:34:36Z","timestamp":1694806476000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Regulating Size and Charge of Liposomes in Microneedles to Enhance Intracellular Drug Delivery Efficiency in Skin for Psoriasis Therapy"],"prefix":"10.1002","volume":"12","author":[{"given":"Fei","family":"Qu","sequence":"first","affiliation":[{"name":"Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica Hubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical Engineering Huazhong University of Science and Technology  Wuhan 430074 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Sun","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica Hubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical Engineering Huazhong University of Science and Technology  Wuhan 430074 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duohang","family":"Bi","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica Hubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical Engineering Huazhong University of Science and Technology  Wuhan 430074 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Peng","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica Hubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical Engineering Huazhong University of Science and Technology  Wuhan 430074 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica Hubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical Engineering Huazhong University of Science and Technology  Wuhan 430074 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Liu","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica Hubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical Engineering Huazhong University of Science and Technology  Wuhan 430074 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianbin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica Hubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical Engineering Huazhong University of Science and Technology  Wuhan 430074 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Union Hospital Tongji Medical College. HUST  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijing","family":"Liu","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica Hubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical Engineering Huazhong University of Science and Technology  Wuhan 430074 China"},{"name":"Shenzhen Huazhong University of Science and Technology Research Institute  Shenzhen 518057 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8230-3923","authenticated-orcid":false,"given":"Jintao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica Hubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical Engineering Huazhong University of Science and Technology  Wuhan 430074 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,23]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.875492"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.69999"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32549-6"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202205847"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abl9165"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.113997"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201305683"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00292"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202110746"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202211330"},{"key":"e_1_2_8_7_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0508-y"},{"key":"e_1_2_8_7_4","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-021-00910-7"},{"key":"e_1_2_8_7_5","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202209986"},{"key":"e_1_2_8_7_6","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201902825"},{"key":"e_1_2_8_7_7","doi-asserted-by":"publisher","DOI":"10.1002\/sstr.202000097"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202004873"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01105"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.06.039"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c11691"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0090-8"},{"key":"e_1_2_8_10_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-022-00529-7"},{"key":"e_1_2_8_10_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2022.114425"},{"key":"e_1_2_8_10_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.04.046"},{"key":"e_1_2_8_10_6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2018.10.037"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2020.11.006"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.12.041"},{"key":"e_1_2_8_11_3","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S315705"},{"key":"e_1_2_8_11_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2022.107819"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.12.014"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe2888"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.07.006"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay7162"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b22693"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00103"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-020-0669-6"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.09.003"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.07.016"},{"key":"e_1_2_8_17_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2021.08.020"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1531"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200900005"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/mp800051m"},{"key":"e_1_2_8_19_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120574"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.01.065"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201802546"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b09655"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.08.017"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.07.002"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-00842-3"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141623"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0232-6"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324506"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200635873"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202003679"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.07.048"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202302314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T12:42:27Z","timestamp":1764420147000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202302314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,23]]},"references-count":54,"journal-issue":{"issue":"31","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/adhm.202302314"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202302314","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,23]]},"assertion":[{"value":"2023-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2302314"}}