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Here the design and proof of concept applications of an ultraswelling microneedle device that enables the facile and efficient loading and transdermal delivery of hydrophilic drugs with different molecular weights is reported. The device consists of a super\u2010hydrophilic hydrogel microneedle array and a resin base substrate. Using a special micromolding technique that involves hydrated crosslinking and cryogenic\u2010demolding, the microneedle part displays a rapid swelling ratio of \u22483800%, enabling the loading of drugs up to 500\u00a0kDa in molecular weight. The drug loading process using the device just involves incubating the microneedle part in a drug solution for 1\u00a0min, followed by 15\u00a0min of drying. The microneedles can easily penetrate the skin under press and detach from the base substrate under shear, thereby releasing the payload. Administration of desired therapeutic agents using the device outperformed conventional administration methods in mitigating psoriasis and eliciting immunity. This biocompatible device, capable of withstanding ethylene oxide sterilization, can enhance the efficacy and accessibility of transdermal therapies in research institutes, hospitals, and even home settings<\/jats:p>","DOI":"10.1002\/adhm.202302406","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T08:38:27Z","timestamp":1697791107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["An Ultraswelling Microneedle Device for Facile and Efficient Drug Loading and Transdermal Delivery"],"prefix":"10.1002","volume":"13","author":[{"given":"Zhiming","family":"Li","sequence":"first","affiliation":[{"name":"Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou Zhejiang 310022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puxuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou Zhejiang 310022 China"},{"name":"College of Materials Science and Engineering Zhejiang University of Technology  Hangzhou Zhejiang 310014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixin","family":"Ling","sequence":"additional","affiliation":[{"name":"Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou Zhejiang 310022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Zheng","sequence":"additional","affiliation":[{"name":"Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou Zhejiang 310022 China"},{"name":"College of Pharmaceutical Sciences Zhejiang University of Technology  Hangzhou Zhejiang 310014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengli","family":"Qu","sequence":"additional","affiliation":[{"name":"Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou Zhejiang 310022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6326-6189","authenticated-orcid":false,"given":"Hao","family":"Chang","sequence":"additional","affiliation":[{"name":"Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences  Hangzhou Zhejiang 310022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1504"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425240802542690"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2022.09.018"},{"key":"e_1_2_10_2_3","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2006.8.369"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.09.025"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2010.09.018"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.201900141"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1304"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501176102"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201606596"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00720-1"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-018-0337-4"},{"key":"e_1_2_10_8_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0508-y"},{"key":"e_1_2_10_8_4","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2182"},{"key":"e_1_2_10_8_5","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3550"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.113919"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2022.12.007"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2019.10.004"},{"key":"e_1_2_10_10_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2022.213151"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202203104"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201702243"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201905910"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/CPAA.S64788"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/0014013042000327724"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(00)00300-X"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201702243"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)61134-5"},{"key":"e_1_2_10_19_2","first-page":"60","volume":"9","author":"Fala L.","year":"2016","journal-title":"Am. 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