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The detection of redox states in its pathological process can effectively help us gain a deeper understanding of the disease. The pair of oxidation\u2013reduction substances peroxynitrite (ONOO<jats:sup>\u2212<\/jats:sup>) and glutathione (GSH) is considered to be closely related to their occurrence and development. Thus, direct visualization of ONOO<jats:sup>\u2212<\/jats:sup> and GSH in diabetes liver disease is critical to evaluate the disease at the molecular level. Herein, two activatable agents NTCF\u2010ONOO<jats:sup>\u2212<\/jats:sup> and NTCF\u2010GSH are prepared for selectively detecting ONOO<jats:sup>\u2212<\/jats:sup> and GSH through protection and deprotection strategies based on hydroxyl and amino groups of near\u2010infrared fluorophore. Fluorescence imaging of exogenous and endogenous ONOO<jats:sup>\u2212<\/jats:sup> and GSH changes in living cells and in vivo is observed. The ONOO<jats:sup>\u2212<\/jats:sup> and GSH level in the diabetes liver disease cellular model are visualized and the possible redox imbalance mechanism related to the oxidized (NAD<jats:sup>+<\/jats:sup>) and reduced (NADH) nicotinamide adenine dinucleotides is explored in this process. Moreover, these probes can sensitively recognize ONOO<jats:sup>\u2212<\/jats:sup> and GSH in the process of oxidative stress resulting from streptozotocin and streptozotocin\/acetaminophen\u2010induced complex diabetic liver disease in vivo. In addition, they can be applied for monitoring the clinical serum sample related with diabetic patients.<\/jats:p>","DOI":"10.1002\/adhm.202302466","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T03:50:42Z","timestamp":1697428242000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["De Novo Design of Near\u2010Infrared Fluorescent Agents Activated by Peroxynitrite and Glutathione\u2010Responsive Imaging for Diabetic Liver Disease"],"prefix":"10.1002","volume":"13","author":[{"given":"Renfeng","family":"Jiang","sequence":"first","affiliation":[{"name":"Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study School of Pharmaceutical Science Hengyang Medical School University of South China  Hengyang Hunan 421002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongshuai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hunan Provincial Clinical Research Center for Metabolic Associated Fatty Liver Disease Clinical Research Institute the Affiliated Nanhua Hospital Hengyang Medical School University of South China  Hengyang Hunan 421002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[{"name":"Hunan Provincial Clinical Research Center for Metabolic Associated Fatty Liver Disease Clinical Research Institute the Affiliated Nanhua Hospital Hengyang Medical School University of South China  Hengyang Hunan 421002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Hunan Provincial Clinical Research Center for Metabolic Associated Fatty Liver Disease Clinical Research Institute the Affiliated Nanhua Hospital Hengyang Medical School University of South China  Hengyang Hunan 421002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longwei","family":"He","sequence":"additional","affiliation":[{"name":"Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study School of Pharmaceutical Science Hengyang Medical School University of South China  Hengyang Hunan 421002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemo\/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University  Changsha 410082 P. 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