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However, the dynamic regulation of mitochondrial rise and demise in impaired chondrocytes and the exact role of mitochondrial metronome sirtuins 3 (SIRT3) is not clarified. Herein, chondrocytes are treated with SIRT3 natural agonist dihydromyricetin (DMY) or chemical antagonist 3\u2010TYP, respectively, to demonstrate the positive action of SIRT3 on preserving cartilage extracellular matrix (ECM). Molecular mechanical investigations disclose that SIRT3\u2010induced chondroprotection depended on the repression of mitochondrial apoptosis (mtApoptosis) and the activation of mitophagy. Inspired by the high\u2010level matrix proteinases and reactive oxygen species (ROS) in the OA environment, by anchoring gelatin methacrylate (GelMA) and benzenediboronic acid (PBA) to hyaluronic acid methacrylate (HAMA) with microfluidic technology, a dual\u2010responsive hydrogel microsphere laden with DMY is tactfully fabricated and named as DMY@HAMA\u2010GelMA\u2010PBA (DMY@HGP). In vivo injection of DMY@HGP ameliorated cartilage abrasion and subchondral bone sclerosis, as well as promoted motor function recovery in post\u2010traumatic OA (PTOA) model via recouping endogenous mtApoptosis and mitophagy balance. Overall, this study unveils a novel mitochondrial dynamic\u2010oriented strategy, holding great promise for the precision treatment of OA.<\/jats:p>","DOI":"10.1002\/adhm.202302475","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T21:13:20Z","timestamp":1694466800000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Retuning Mitochondrial Apoptosis\/Mitophagy Balance via SIRT3\u2010Energized and Microenvironment\u2010Modulated Hydrogel Microspheres to Impede Osteoarthritis"],"prefix":"10.1002","volume":"12","author":[{"given":"Xiaowei","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Orthopaedics The First Affiliated Hospital of Soochow University Soochow University  Suzhou 215006 China"},{"name":"Orthopaedic Institute Medical College Soochow University  Suzhou 215007 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