{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:47:04Z","timestamp":1792043224741,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"25","license":[{"start":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR079211"],"award-info":[{"award-number":["R01AR079211"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"publisher","award":["ECUC4\u201012792"],"award-info":[{"award-number":["ECUC4\u201012792"]}],"id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Conductive biomaterials may capture native or exogenous bioelectric signaling, but incorporation of conductive moieties is limited by cytotoxicity, poor injectability, or insufficient stimulation. Microgel annealed scaffolds are promising as hydrogel\u2010based materials due to their inherent void space that facilitates cell migration and proliferation better than nanoporous bulk hydrogels. Conductive microgels are\u00a0generated from poly(ethylene) glycol (PEG and poly(3,4\u2010ethylenedioxythiophene) polystyrene sulfonate (PEDOT: PSS) to explore the interplay of void volume and conductivity on myogenic differentiation. PEDOT: PSS increases\u00a0microgel conductivity two\u2010fold while maintaining stiffness, annealing strength, and viability of associated myoblastic cells. C2C12 myoblasts exhibit\u00a0increases in the late\u2010stage differentiation marker myosin heavy chain as a function of both porosity and conductivity. Myogenin, an earlier marker, is\u00a0influenced only by porosity. Human skeletal muscle\u2010derived cells exhibit\u00a0increased\n                    <jats:italic>Myod1<\/jats:italic>\n                    , insulin like growth factor\u20101, and insulin\u2010like growth factor binding protein 2 at earlier time points on conductive microgel scaffolds compared to non\u2010conductive scaffolds. They also secrete\u00a0more vascular endothelial growth factor at early time points and express\u00a0factors that led to macrophage polarization patterns observe during muscle repair. These data indicate that conductivity aids myogenic differentiation of myogenic cell lines and primary cells, motivating the need for future translational studies to promote muscle repair.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202302500","type":"journal-article","created":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T09:35:13Z","timestamp":1702114513000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Conductive Microgel Annealed Scaffolds Enhance Myogenic Potential of Myoblastic Cells"],"prefix":"10.1002","volume":"13","author":[{"given":"Alena","family":"Casella","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering University of California Davis  Davis CA 95616 USA"},{"name":"Department of Orthopaedic Surgery School of Medicine UC Davis Health  Sacramento CA 95817 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Lowen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of California Davis  Davis CA 95616 USA"},{"name":"Department of Orthopaedic Surgery School of Medicine UC Davis Health  Sacramento CA 95817 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine H.","family":"Griffin","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery School of Medicine UC Davis Health  Sacramento CA 95817 USA"},{"name":"School of Veterinary Medicine University of California Davis  Davis CA 95616 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Shimamoto","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of California Davis  Davis CA 95616 USA"},{"name":"Department of Orthopaedic Surgery School of Medicine UC Davis Health  Sacramento CA 95817 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Ramos\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery School of Medicine UC Davis Health  Sacramento CA 95817 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Panitch","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Georgia Institute of Technology  Atlanta GA 30332 USA"},{"name":"Department of Biomedical Engineering Emory University  Atlanta GA 30322 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1673-3335","authenticated-orcid":false,"given":"J. 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