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It is characterized by the destruction of cartilage and inflammatory reactions. High levels of reactive oxygen species (ROS) cause oxidative stress, which damages lipids, proteins, and DNA, leading to cell damage and death. Furthermore, ROS also induces the production of inflammatory cytokines and cell chemotaxis, further worsening the inflammatory response and damaging cartilage resulted in limited movement. Herein, this work reports a dual\u2010functional injectable hydrogel, which can help inhibit inflammation by scavenging ROS and provide lubrication to reduce wear and tear on the joints. To create the hydrogel, 3\u2010aminophenylboronic acid modified hyaluronic acid is synthesized, then which is crosslinked with hydroxyl\u2010containing polyvinyl alcohol\u00a0(PVA) to construct a dual dynamic covalent crosslinked hydrogel oHA\u2010PBA\u2010PVA gel,\u00a0Gel (HPP). The hydrogel mentioned here possesses a unique bond structure that allows it to be injected, self\u2010heal, and provide lubrication. This innovative approach offers a new possibility for treating osteoarthritis by combining anti\u2010inflammatory and lubrication effects.<\/jats:p>","DOI":"10.1002\/adhm.202302551","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T22:30:53Z","timestamp":1700605853000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Dual\u2010Functional Injectable Hydrogel for Osteoarthritis Treatments"],"prefix":"10.1002","volume":"13","author":[{"given":"Lei","family":"Lei","sequence":"first","affiliation":[{"name":"NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients and Department of Pharmaceutics School of Pharmacy China Pharmaceutical University  24 Tong Jia Xiang Nanjing 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Cong","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for 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