{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:31:37Z","timestamp":1792794697862,"version":"4.5.0"},"reference-count":76,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18K12091"],"award-info":[{"award-number":["JP18K12091"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21H03833"],"award-info":[{"award-number":["JP21H03833"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23K18442"],"award-info":[{"award-number":["JP23K18442"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Implantable biomaterials trigger foreign body reactions (FBRs), which reduces the functional life of medical devices and prevents effective tissue regeneration. Although existing therapeutic approaches can circumvent collagen\u2010rich fibrotic encapsulation secondary to FBRs, they disrupt native tissue repair. Herein, a new surface engineering strategy in which an apoptotic\u2010mimetic, immunomodulatory, phosphatidylserine liposome (PSL) is released from an implant coating to induce the formation of a macrophage phenotype that mitigates FBRs and improves tissue healing is described. PSL\u2010multilayers constructed on implant surfaces via the layer\u2010by\u2010layer method release PSLs over a 1\u2010month period. In rat muscles, poly(etheretherketone) (PEEK), a nondegradable polymer implant model, induces FBRs with dense fibrotic scarring under an aberrant cellular profile that recruits high levels of inflammatory infiltrates, foreign body giant cells (FBGCs), scar\u2010forming myofibroblasts, and inflammatory M1\u2010like macrophages but negligible amounts of anti\u2010inflammatory M2\u2010like phenotypes. However, the PSL\u2010multilayer coating markedly diminishes these detrimental signatures by shifting the macrophage phenotype. Unlike other therapeutics, PSL\u2010multilayered coatings also stimulate muscle regeneration. This study demonstrates that PSL\u2010multilayered coatings are effective in eliminating FBRs and promoting regeneration, hence offering potent and broad applications for implantable biomaterials.<\/jats:p>","DOI":"10.1002\/adhm.202302611","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T11:05:45Z","timestamp":1702551945000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Releasable, Immune\u2010Instructive, Bioinspired Multilayer Coating Resists Implant\u2010Induced Fibrosis while Accelerating Tissue Repair"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9700-4531","authenticated-orcid":false,"given":"Riki","family":"Toita","sequence":"first","affiliation":[{"name":"Biomedical Research Institute National Institute of Advanced Industrial Science and Technology (AIST)  1\u20108\u201031 Midorigaoka Ikeda Osaka 563\u20108577 Japan"},{"name":"AIST\u2010Osaka University Advanced Photonics and Biosensing Open Innovation Laboratory AIST  2\u20101 Yamadaoka Suita Osaka 565\u20100871 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Niterra Co., Ltd.  2808 Iwasaki Komaki Aichi 485\u20138510 Japan"},{"name":"NGK Spark Plug\u2010AIST Healthcare Materials Cooperative Research Laboratory  2266\u201398 Anagahora Shimoshidami, Moriyama\u2010ku Nagoya Aichi 463\u20138560 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0784-2238","authenticated-orcid":false,"given":"Akira","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Faculty of Dental Science Kyushu University  3\u20101\u20101 Maidashi Higashi\u2010ku Fukuoka 812\u20138582 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9229-3063","authenticated-orcid":false,"given":"Jeong\u2010Hun","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Biopharmaceutics and Pharmacokinetics National Cerebral and Cardiovascular Center Research Institute  6\u20101 Shinmachi, Kishibe Suita Osaka 564\u20138565 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinjiro","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Niterra Co., Ltd.  2808 Iwasaki Komaki Aichi 485\u20138510 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,19]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-019-0150-z"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202004023"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202007226"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.06.004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202102087"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.03.038"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00895"},{"key":"e_1_2_10_8_1","volume":"8","author":"Polderman J. A. W.","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114147"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108327"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2014.0487"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.07.019"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202101536"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.09.004"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121586"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.11.043"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/606404"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00050"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13122-8"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-021-00648-0"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20102"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00707.2009"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21212"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00518.2005"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0167-y"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2016.11"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.09.018"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC03320K"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.112492"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.12.052"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.10.024"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202207847"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885328218786005"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5TB01679G"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2018.09.032"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.03.007"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00605"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63265-8"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1246\/cl.1996.739"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.105.061432"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2011.tb00387.x"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00043.2011"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1288"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8792"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121087"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202201378"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202104899"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00739-4"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00722-z"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2014.12.002"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3073"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.05.039"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0065-8"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0082-x"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202201656"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202207030"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118203"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13867"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00087"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00735.2009"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120768"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.10.019"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.04.115"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.06.057"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100041"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202200311"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202200045"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.118.007023"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-021-00193-5"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2017.02.006"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.135"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1806908115"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf201864v"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64762-3"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.36764"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-022-06656-5"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202302611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T21:42:22Z","timestamp":1759786942000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202302611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,19]]},"references-count":76,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/adhm.202302611"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202302611","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,19]]},"assertion":[{"value":"2023-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2302611"}}