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AKI is accompanied by the generation of reactive oxygen species (ROS) and inflammation. Therefore, the management of ROS and inflammation is a potential strategy for AKI mitigation. Herein, polyethylene glycol\u2010coated osmium nanozyme\u2010based antidotes (<jats:bold>Os<\/jats:bold>) are developed for imaging\u2010guided photothermal therapy (PTT) in combination with cisplatin (<jats:bold>Pt<\/jats:bold>); while, avoiding AKI induced by high\u2010dose <jats:bold>Pt<\/jats:bold>. <jats:bold>Os<\/jats:bold> nanoantidotes can enhance the efficiency of tumor treatment during combined PTT and chemotherapy and inhibit tumor metastasis by improving the hypoxic and inflammatory tumor microenvironment. <jats:bold>Os<\/jats:bold> nanoantidotes preferentially accumulate in the kidney because of their 2\u2010nm size distribution; and then, regulate inflammation by scavenging ROS and generating oxygen to alleviate <jats:bold>Pt<\/jats:bold>\u2010induced AKI. <jats:bold>Os<\/jats:bold> nanoantidotes can be cleared from the kidneys by urine excretion but can be degraded under hydrogen peroxide stimulation, reducing the bio\u2010retention of these compounds. By integrating PTT with inflammatory regulation, <jats:bold>Os<\/jats:bold> nanoantidotes have the potential to reduce the side effects of chemotherapy, offering an alternative route for the clinical management of cancer patients with chemotherapy\u2010induced AKI.<\/jats:p>","DOI":"10.1002\/adhm.202302729","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T21:03:07Z","timestamp":1702587787000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Biodegradable Osmium Nanoantidotes for Photothermal\u2010\/Chemo\u2010 Combined Treatment and to Prevent Chemotherapy\u2010Induced Acute Kidney Injury"],"prefix":"10.1002","volume":"13","author":[{"given":"Qi","family":"Long","sequence":"first","affiliation":[{"name":"Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target &amp; Clinical Pharmacology the NMPA and State Key Laboratory of Respiratory Disease the Fifth 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