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Hence, the quest for a synergistic treatment modality and a targeted delivery approach to effectively address EC has become imperative. In this study, an acid\u2010responsive release nanosystem (Bev\u2010IR820@Fe\n                    <jats:sup>III<\/jats:sup>\n                    TA) that involves the conjugation of bevacizumab, an anti\u2010angiogenic monoclonal antibody, with TA and Fe\n                    <jats:sup>3+<\/jats:sup>\n                    to form a metal\u2010phenolic network, followed by loading with the near\u2010infrared photothermal agent (IR820) to achieve combinational therapy, is designed. The construction of Bev\u2010IR820@Fe\n                    <jats:sup>III<\/jats:sup>\n                    TA can be realized through a facile self\u2010assembly process. The Bev\u2010IR820@Fe\n                    <jats:sup>III<\/jats:sup>\n                    TA exhibits tumor\u2010targeting capabilities and synergistic therapeutic effects, encompassing anti\u2010angiogenic therapy, photothermal therapy (PTT), and ferroptosis therapy (FT). Bev\u2010IR820@Fe\n                    <jats:sup>III<\/jats:sup>\n                    TA exhibits remarkable proficiency in delivering drugs to EC tissue through its pH\u2010responsive release properties. Consequently, bevacizumab exerts its therapeutic effects by obstructing tumor angiogenesis, thereby impeding tumor growth. Meanwhile, PTT facilitates localized thermal ablation at the tumor site, directly eradicating EC cells. FT synergistically collaborates with PTT, giving rise to the formation of a reactive oxygen species (ROS) storm, subsequently culminating in the demise of EC cells. In summary, this amalgamated treatment modality carries substantial promise for synergistically impeding EC progression and showcases auspicious prospects for future EC treatment.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202302787","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T23:50:12Z","timestamp":1700610612000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Self\u2010Assembled Acid\u2010Responsive Nanosystem for Synergistic Anti\u2010Angiogenic\/Photothermal\/Ferroptosis Therapy against Esophageal Cancer"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1432-5573","authenticated-orcid":false,"given":"Xiaokun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery West China Hospital Sichuan University  Chengdu 610044 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