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Excess intraluminal H\n                    <jats:sub>2<\/jats:sub>\n                    S in the GI tract has been implicated in inflammatory bowel disease and neurodegenerative disorders; however, the role of H\n                    <jats:sub>2<\/jats:sub>\n                    S in disease pathogenesis and progression is unclear. Herein, an electrochemical gas\u2010sensing ingestible capsule is developed to enable real\u2010time, wireless amperometric measurement of H\n                    <jats:sub>2<\/jats:sub>\n                    S in GI conditions. A gold (Au) three\u2010electrode sensor is modified with a Nafion solid\u2010polymer electrolyte (Nafion\u2010Au) to enhance selectivity toward H\n                    <jats:sub>2<\/jats:sub>\n                    S in humid environments. The Nafion\u2010Au sensor\u2010integrated capsule shows a linear current response in H\n                    <jats:sub>2<\/jats:sub>\n                    S concentration ranging from 0.21 to 4.5\u00a0ppm (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 0.954) with a normalized sensitivity of 12.4% ppm\n                    <jats:sup>\u22121<\/jats:sup>\n                    when evaluated in a benchtop setting. The sensor proves highly selective toward H\n                    <jats:sub>2<\/jats:sub>\n                    S in the presence of known interferent gases, such as hydrogen (H\n                    <jats:sub>2<\/jats:sub>\n                    ), with a selectivity ratio of H\n                    <jats:sub>2<\/jats:sub>\n                    S:H\n                    <jats:sub>2<\/jats:sub>\n                    = 1340, as well as toward methane (CH\n                    <jats:sub>4<\/jats:sub>\n                    ) and carbon dioxide (CO\n                    <jats:sub>2<\/jats:sub>\n                    ). The packaged capsule demonstrates reliable wireless communication through abdominal tissue analogues, comparable to GI dielectric properties. Also, an assessment of sensor drift and threshold\u2010based notification is investigated, showing potential for in vivo application. Thus, the developed H\n                    <jats:sub>2<\/jats:sub>\n                    S capsule platform provides an analytical tool to uncover the complex biology\u2010modulating effects of intraluminal H\n                    <jats:sub>2<\/jats:sub>\n                    S.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202302897","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T20:33:21Z","timestamp":1701376401000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Miniaturized Capsule System Toward Real\u2010Time Electrochemical Detection of H\n                    <sub>2<\/sub>\n                    S in the Gastrointestinal Tract"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2693-6400","authenticated-orcid":false,"given":"Justin M.","family":"Stine","sequence":"first","affiliation":[{"name":"Department of Electrical and Computer Engineering University of Maryland  College Park MD 20742 USA"},{"name":"Institute for Systems Research University of Maryland  College Park MD 20742 USA"},{"name":"Fischell Institute for Biomedical Devices University of Maryland  College Park MD 20742 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8994-3223","authenticated-orcid":false,"given":"Katie L.","family":"Ruland","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering University of Maryland  College Park MD 20742 USA"},{"name":"Institute for Systems Research University of Maryland  College Park MD 20742 USA"},{"name":"Fischell Institute for Biomedical Devices University of Maryland  College Park MD 20742 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5713-5059","authenticated-orcid":false,"given":"Luke A.","family":"Beardslee","sequence":"additional","affiliation":[{"name":"Institute for Systems Research University of Maryland  College Park MD 20742 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9567-5822","authenticated-orcid":false,"given":"Joshua A.","family":"Levy","sequence":"additional","affiliation":[{"name":"Institute for Systems Research University of Maryland  College Park MD 20742 USA"},{"name":"Fischell Institute for Biomedical Devices University of Maryland  College Park MD 20742 USA"},{"name":"Department of Materials Science and Engineering University of Maryland  College Park MD 20742 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Abianeh","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering University of Maryland  College Park MD 20742 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6488-5886","authenticated-orcid":false,"given":"Santiago","family":"Botasini","sequence":"additional","affiliation":[{"name":"Institute for Systems Research University of Maryland  College Park MD 20742 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8727-683X","authenticated-orcid":false,"given":"Pankaj J.","family":"Pasricha","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Mayo Clinic Hospital  Phoenix AZ 85054 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3716-4901","authenticated-orcid":false,"given":"Reza","family":"Ghodssi","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering University of Maryland  College Park MD 20742 USA"},{"name":"Institute for Systems Research University of Maryland  College Park MD 20742 USA"},{"name":"Fischell Institute for Biomedical Devices University of Maryland  College Park MD 20742 USA"},{"name":"Department of Materials Science and Engineering University of Maryland  College Park MD 20742 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,10]]},"reference":[{"key":"e_1_2_8_1_1","first-page":"17","volume":"13","author":"Bull M. 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