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The present study investigates a NGC fabrication strategy based on bredigite (BRT, Ca<jats:sub>7<\/jats:sub>MgSi<jats:sub>4<\/jats:sub>O<jats:sub>16<\/jats:sub>) bioceramic for the treatment of peripheral nerve injury. Here, BRT bioceramic shows good biocompatibility and sustainable release of Ca<jats:sup>2+<\/jats:sup>, Mg<jats:sup>2+<\/jats:sup>, and Si<jats:sup>4+<\/jats:sup> ions. Both BRT extracts and BRT\u2010incorporating electrospun membranes promote the proliferation and myelination potential of RSC96 cells, as well as accelerate vascular formation by human umbilical vein endothelial cells. Notably, BRT facilitates RAW 264.7 cell polarization to the pro\u2010healing phenotype under LPS\u2010induced inflammatory stimulation. More importantly, the macrophages activated by BRT in turn promote RSC96 cell migration and remyelination. In a rat sciatic nerve defect model, improved electrophysiological performance and alleviated gastrocnemius muscle atrophy are observed at 12 weeks post\u2010implantation. Further experiments verify that BRT\u2010loaded NGC facilitates axonal regrowth and revascularization with high M2\u2010like macrophage infiltration. These findings support the beneficial effects of BRT for creating a pro\u2010healing immune microenvironment and orchestrating multicellular processes associated with functional nerve regeneration, indicating the potential of rationally engineered bioceramics as safe, effective, and economical materials for peripheral nerve repair.<\/jats:p>","DOI":"10.1002\/adhm.202302994","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T01:21:30Z","timestamp":1700184090000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Bredigite\u2010Based Bioactive Nerve Guidance Conduit for Pro\u2010Healing Macrophage Polarization and Peripheral Nerve Regeneration"],"prefix":"10.1002","volume":"13","author":[{"given":"Yaowei","family":"Xuan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral 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