{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:31:51Z","timestamp":1787509911433,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970982"],"award-info":[{"award-number":["81970982"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Remineralized dentin with an antibacterial ability is still a significant challenge in dentistry. Previously, a polyelectrolyte\u2010calcium complexes pre\u2010precursor (PCCP) process is proposed for rapid collagen mineralization. In the present study, the expansion concept of the PCCP process is explored by replacing the calcium with other cations, such as strontium. The results of transmission electron microscopy (TEM), 3D stochastic optical reconstruction microscopy, energy\u2010dispersive X\u2010ray analysis, Fourier transform infrared spectroscopy, and high\u2010resolution TEM with selected area electron diffraction demonstrate that biomimetic mineralization of collagen fibrils and demineralized dentin could be fulfilled with Sr&amp;F\u2010codoped hydroxyapatite (HAp) after they are treated with poly\u2010aspartic acid\u2010strontium (PAsp\u2010Sr) suspension followed by a phosphate&amp;fluoride solution. Moreover, dentin remineralized with Sr&amp;F\u2010codoped HAp exhibits in vitro and in vivo antibacterial ability against\n                    <jats:italic>Streptococcus mutans<\/jats:italic>\n                    . The cytotoxicity and oral mucosa irritation tests reveal excellent biocompatibility of mineralization mediums (PAsp\u2010Sr suspension and phosphate&amp;fluoride solution). The demineralized dentin's mechanical properties (elastic modulus and microhardness) could be restored almost to that of the intact dentin. Hence, the expansion concept of the PCCP process that replaces calcium ions with some cationic ions along with fluorine opens up new horizons for generating antibacterial remineralized dentin containing ions\u2010doped HAp with excellent biocompatibility via biomimetic mineralization technology.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202303002","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T03:14:44Z","timestamp":1701227684000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Polyelectrolyte\u2010Cation Complexes Using PAsp\u2010Sr Complexes Induce Biomimetic Mineralization with Antibacterial Ability"],"prefix":"10.1002","volume":"13","author":[{"given":"Yuedan","family":"Xu","sequence":"first","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral 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