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Nanogels are examined for their rheological and physical properties. The biocompatibility studies will be assessed on auditory and macrophage cell lines by investigating the impact of nanogels on cellular viability, mitochondrial respiration, glycolysis, intracellular oxidative stress, inflammatory profile, and macrophage polarization. Novel ther nanogels based on bile acid and beta\u2010cyclodextrin show preserved porous nanogels' inner structure, exhibit non\u2010Newtonian, shear\u2010thinning fluid behavior, have fast gelation at 37\u00a0\u00b0C and minimal albumin adsorption on the surface. The nanogels have minimal impact on cellular viability, mitochondrial respiration, glycolysis, intracellular oxidative stress, and inflammatory profile of the auditory cell line House Ear Institute\u2010Organ of Corti 1 after 24\u00a0h incubation. Nanogel exposure of 24\u00a0h to macrophage cell line RAW264.7 leads to decreased viability, mitochondrial dysfunction, and increased intracellular ROS and inflammatory cytokines. However, polarization changes from M2 anti\u2010inflammatory to M1 pro\u2010inflammatory macrophages are minimal, and inflammatory products of RAW264.7 macrophages do not overly disrupt the survivability of HEI\u2010OC1 cells. Based on these results, thermoresponsive bile acid and cyclodextrin nanogels can be potential drug delivery vehicles for inner ear drug delivery.<\/jats:p>","DOI":"10.1002\/adhm.202303149","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T20:30:02Z","timestamp":1711053002000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Biotechnological Effects of Advanced Smart\u2010Bile Acid Cyclodextrin\u2010Based Nanogels for Ear Delivery and Treatment of Hearing Loss"],"prefix":"10.1002","volume":"13","author":[{"given":"Bozica","family":"Kovacevic","sequence":"first","affiliation":[{"name":"The Biotechnology and Drug Development Research Laboratory Curtin Medical School &amp; Curtin Health Innovation Research Institute Curtin University  Bentley Perth WA 6102 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susbin Raj","family":"Wagle","sequence":"additional","affiliation":[{"name":"The Biotechnology and Drug Development Research Laboratory Curtin Medical School &amp; 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