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This review discusses the development of P\u2010MPS as an integration of patient\u2010derived samples, including patient\u2010derived cells, organoids, and induced pluripotent stem cells, into well\u2010defined MPSs. Emphasizing the necessity of P\u2010MPS development, its significance as a nonclinical assessment approach that bridges the gap between traditional in vitro models and clinical outcomes is highlighted. Additionally, guidance is provided for engineering approaches to develop microfluidic devices and high\u2010content analysis for P\u2010MPSs, enabling high biological relevance and high\u2010throughput experimentation. The practical implications of the P\u2010MPS are further examined by exploring the clinically relevant outcomes obtained from various types of patient\u2010derived samples. The construction and analysis of these diverse samples within the P\u2010MPS have resulted in physiologically relevant data, paving the way for the development of personalized treatment strategies. 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