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To overcome these problems, a novel hydrogel adhesive (named CFT hydrogel) is rapidly constructed using a one\u2010step method based on dual\u2010dynamic covalent cross\u2010linking. Compared with the commercial oral patches, the CFT hydrogel shows superior in vivo (rat tongue) wet tissue adhesion performance. Additionally, the CFT hydrogel exhibits unique acid\u2010responsive properties, thereby facilitating the release of bioactive molecule tannic acid in the acidic diabetic wound microenvironment. And a series of in vitro experiments substantiate the favorable biocompatibility and bioactivity properties (including antibacterial, antioxidative, anti\u2010inflammatory, and angiogenetic effects) exhibited by CFT hydrogel. Moreover, in vivo experiments conducted on a diabetic rat model with oral mucosal defects demonstrate that the CFT hydrogel exhibits significant efficacy in protecting against mucosal wounds, alleviating inflammatory reactions, thereby facilitating the wound\u2010healing process. Taken together, this study provides a promising and comprehensive therapeutic option with great potential for the clinical management of oral mucosa defects in diabetic patients.<\/jats:p>","DOI":"10.1002\/adhm.202303252","type":"journal-article","created":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T06:38:07Z","timestamp":1705819087000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["One\u2010Step Synthesis of Hydrogel Adhesive with Acid\u2010Responsive Tannin Release for Diabetic Oral Mucosa Defects Healing"],"prefix":"10.1002","volume":"13","author":[{"given":"Kaize","family":"Su","sequence":"first","affiliation":[{"name":"School of Pharmacy and Food Engineering Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine Wuyi University  Jiangmen 529020 P. R. China"},{"name":"International Healthcare Innovation Institute (Jiangmen)  Jiangmen 529040 P. R. 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