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Although oxygen therapy has demonstrated efficacy in promoting healing, its therapeutic impact remains suboptimal due to unsustainable oxygenation. Here, this work proposes an oxygen\u2010releasing hydrogel patch embedded with polyethylene glycol\u2010modified calcium peroxide microparticles, which sustainably releases oxygen for 7 days without requiring any supplementary conditions. The released oxygen effectively promotes cell migration and angiogenesis under hypoxic conditions as validated in vitro. The in vivo tests in diabetic mice models show that the sustainably released oxygen significantly facilitates the synthesis of ECM, induces angiogenesis, and decreases the expression of inflammatory cytokines, achieving a diabetic wound healing rate of 84.2% on day 7, outperforming the existing oxygen\u2010releasing approaches. Moreover, the proposed hydrogel patch is designed with porous, soft, antibacterial, biodegradable, and storage stability for 15 days. The proposed hydrogel patch is expected to be promising in clinics treating diabetic wounds.<\/jats:p>","DOI":"10.1002\/adhm.202303314","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T14:59:45Z","timestamp":1711983585000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Calcium Peroxide\u2010Based Hydrogel Patch with Sustainable Oxygenation for Diabetic Wound Healing"],"prefix":"10.1002","volume":"13","author":[{"given":"Na","family":"Li","sequence":"first","affiliation":[{"name":"School of Integrated Circuits Huazhong University of Science and Technology  Wuhan 430074 China"},{"name":"Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology  Wuhan 430074 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohuan","family":"Lu","sequence":"additional","affiliation":[{"name":"Research Center for Tissue Engineering and Regenerative Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"},{"name":"Department of Gastrointestinal Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueying","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Integrated Circuits Huazhong University of Science and Technology  Wuhan 430074 China"},{"name":"Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology  Wuhan 430074 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Ning","sequence":"additional","affiliation":[{"name":"School of Integrated Circuits Huazhong University of Science and Technology  Wuhan 430074 China"},{"name":"Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology  Wuhan 430074 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Integrated Circuits Huazhong University of Science and Technology  Wuhan 430074 China"},{"name":"Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology  Wuhan 430074 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Integrated Circuits Huazhong University of Science and Technology  Wuhan 430074 China"},{"name":"Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology  Wuhan 430074 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9330-0728","authenticated-orcid":false,"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Center for Tissue Engineering and Regenerative Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"},{"name":"Department of Gastrointestinal Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5716-6587","authenticated-orcid":false,"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Center for Tissue Engineering and Regenerative Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"},{"name":"Department of Clinical Laboratory Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1775-4605","authenticated-orcid":false,"given":"Jianfeng","family":"Zang","sequence":"additional","affiliation":[{"name":"School of Integrated Circuits Huazhong University of Science and Technology  Wuhan 430074 China"},{"name":"Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology  Wuhan 430074 China"},{"name":"The State Key Laboratory of Intelligent Manufacturing Equipment and Technology School of Mechanical Science and Engineering Huazhong University of Science and Technology  Wuhan 430074 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,9]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.2.217"},{"key":"e_1_2_9_2_1","first-page":"8","volume":"20","author":"Leone S.","year":"2012","journal-title":"Infez. 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