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Herein, a laser\u2010integrated magnetic actuation system that actively delivers doxorubicin (DOX)\u2010grafted magnetic nanorobot collectives to the tumor site in model mice for local hyperthermia and chemotherapy is reported. With intraluminal movements controlled by a torque\u2010force hybrid magnetic field, these magnetic nanorobots gather at a fixed point coinciding with the position of the localization laser, moving upward against gravity over a long distance and targeting tumor sites under ultrasound imaging guidance. Because aggregation enhances the photothermal effect, controlled local DOX release is achieved under near\u2010infrared laser irradiation. The targeted on\u2010demand photothermal therapy of multiple PM carcinomas while minimizing off\u2010target tissue damage is demonstrated. Additionally, a localization\/treatment dual\u2010functional laser\u2010integrated magnetic actuation system is developed and validated in vivo, offering a potentially clinically feasible drug delivery strategy for targeting PM and other intraluminal tumors.<\/jats:p>","DOI":"10.1002\/adhm.202303361","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T02:38:02Z","timestamp":1703039882000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Dual\u2010Functional Laser\u2010Guided Magnetic Nanorobot Collectives against Gravity for On\u2010Demand Thermo\u2010Chemotherapy of Peritoneal Metastasis"],"prefix":"10.1002","volume":"13","author":[{"given":"Longchen","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Ultrasound in Medicine Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  No. 600, Yishan Road Shanghai 200233 P. 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