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Measuring physiological parameters to quantify sleep quality without uncomfortable user experience remains highly desired but a challenge. Here, this work develops a soft bioelectronic patch to perform simultaneous respiration and cardiovascular monitoring during sleep in a wearable and non\u2010invasive manner. The soft bioelectronic patch system is mainly composed of a pressure sensor, a flexible printed circuit for signal processing, and a soft thermoplastic urethane mold for assembling different functional modules. The soft bioelectronic patch holds a sensitivity of &gt;0.12\u00a0V\u00a0kPa<jats:sup>\u22121<\/jats:sup> and a remarkable low\u2010frequency response from 0.5 to 15\u00a0Hz. It is demonstrated to continuously monitor respiration and heartbeat during the whole night, which could be harnessed for sleep monitoring and obstructive sleep apnea\u2010hypopnea syndrome diagnosis. The reported soft bioelectronic patch represents a simple and convenient platform technology for sleep study.<\/jats:p>","DOI":"10.1002\/adhm.202303479","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T20:14:21Z","timestamp":1701116061000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A Soft Bioelectronic Patch for Simultaneous Respiratory and Cardiovascular Monitoring"],"prefix":"10.1002","volume":"13","author":[{"given":"Xue","family":"Wang","sequence":"first","affiliation":[{"name":"College of Physics and Electronic Engineering Chongqing Normal University  Chongqing 401331 China"},{"name":"Department of Bioengineering University of California Los Angeles CA 90095 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7861-5596","authenticated-orcid":false,"given":"Xiao","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of California Los Angeles CA 90095 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Optoelectronic Engineering Key Laboratory of Optoelectronic Technology and Systems Ministry of Education Chongqing University  Chongqing 400044 P. 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