{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:19:25Z","timestamp":1786976365576,"version":"build-2736575974"},"reference-count":66,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970982"],"award-info":[{"award-number":["81970982"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371009"],"award-info":[{"award-number":["82371009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004863","name":"Zhejiang Chinese Medical University","doi-asserted-by":"publisher","award":["ZJCLA\u2010IACUC\u201020010344"],"award-info":[{"award-number":["ZJCLA\u2010IACUC\u201020010344"]}],"id":[{"id":"10.13039\/501100004863","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004863","name":"Zhejiang Chinese Medical University","doi-asserted-by":"publisher","award":["IACUC\u201020221128\u201002"],"award-info":[{"award-number":["IACUC\u201020221128\u201002"]}],"id":[{"id":"10.13039\/501100004863","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Amphiphilic biomolecules are abundant in mineralization front of biological hard tissues, which play a vital role in osteogenesis and dental hard tissue formation. Amphiphilic biomolecules function as biosurfactants, however, their biosurfactant role in biomineralization process has never been investigated. This study, for the first time, demonstrates that aggregated amorphous calcium phosphate (ACP) nanoparticles can be reversed into dispersed ultrasmall prenucleation clusters (PNCs) via breakdown and dispersion of the ACP nanoparticles by a surfactant. The reduced surface energy of ACP@TPGS and the electrostatic interaction between calcium ions and the pair electrons on oxygen atoms of C\u2010O\u2010C of D\u2010\u03b1\u2010tocopheryl polyethylene glycol succinate (TPGS) provide driving force for breakdown and dispersion of ACP nanoparticles into ultrasmall PNCs which promote in vitro and in vivo biomimetic mineralization. The ACP@TPGS possesses excellent biocompatibility without any irritations to oral mucosa and dental pulp. This study not only introduces surfactant into biomimetic mineralization field, but also excites attention to the neglected biosurfactant role during biomineralization process.<\/jats:p>","DOI":"10.1002\/adhm.202303488","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T08:40:47Z","timestamp":1706085647000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Reversion of ACP Nanoparticles into Prenucleation Clusters via Surfactant for Promoting Biomimetic Mineralization: A Physicochemical Understanding of Biosurfactant Role in Biomineralization Process"],"prefix":"10.1002","volume":"13","author":[{"given":"Dongni","family":"Shen","sequence":"first","affiliation":[{"name":"Stomatology Hospital School of Stomatology Zhejiang University School of Medicine Zhejiang Provincial Clinical Research Center for Oral Diseases Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province  Hangzhou Zhejiang 310000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihuai","family":"Zhou","sequence":"additional","affiliation":[{"name":"Stomatology Hospital School of Stomatology Zhejiang University School of Medicine Zhejiang Provincial Clinical Research Center for Oral Diseases Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province  Hangzhou Zhejiang 310000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuedan","family":"Xu","sequence":"additional","affiliation":[{"name":"Stomatology Hospital School of Stomatology Zhejiang University School of Medicine Zhejiang Provincial Clinical Research Center for Oral Diseases Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province  Hangzhou Zhejiang 310000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyu","family":"Shao","sequence":"additional","affiliation":[{"name":"Stomatology Hospital School of Stomatology Zhejiang University School of Medicine Zhejiang Provincial Clinical Research Center for Oral Diseases Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province  Hangzhou Zhejiang 310000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Shi","sequence":"additional","affiliation":[{"name":"Stomatology Hospital School of Stomatology Zhejiang University School of Medicine Zhejiang Provincial Clinical Research Center for Oral Diseases Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province  Hangzhou Zhejiang 310000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Zhao","sequence":"additional","affiliation":[{"name":"Stomatology Hospital School of Stomatology Zhejiang University School of Medicine Zhejiang Provincial Clinical Research Center for Oral Diseases Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province  Hangzhou Zhejiang 310000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruikang","family":"Tang","sequence":"additional","affiliation":[{"name":"Center for Biomaterials and Biopathways Department of Chemistry Zhejiang University  Hangzhou Zhejiang Province 310000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihua","family":"Pan","sequence":"additional","affiliation":[{"name":"Qiushi Academy for Advanced Studies Zhejiang University  Hangzhou Zhejiang Province 310000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengfei","family":"Yu","sequence":"additional","affiliation":[{"name":"Stomatology Hospital School of Stomatology Zhejiang University School of Medicine Zhejiang Provincial Clinical Research Center for Oral Diseases Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province  Hangzhou Zhejiang 310000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Hannig","sequence":"additional","affiliation":[{"name":"Clinic of Operative Dentistry Periodontology and Preventive Dentistry Saarland University  66424 Homburg Saarland Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9444-1856","authenticated-orcid":false,"given":"Baiping","family":"Fu","sequence":"additional","affiliation":[{"name":"Stomatology Hospital School of Stomatology Zhejiang University School of Medicine Zhejiang Provincial Clinical Research Center for Oral Diseases Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province  Hangzhou Zhejiang 310000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31146-8"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-022-00167-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19010242"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2018.06.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2018.04.009"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2013.07.013"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S290254"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512454296"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06570-x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8NR02078G"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b01719"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.7b00378"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201605903"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36618"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502718103"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202004418"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2875"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CP05261H"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03041-1"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2011.10.005"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2011.04.014"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05006-w"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345221103145"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201800873"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax0672"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.04.029"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0914218107"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202301231"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202207951"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2020.102340"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.8b00755"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201802915"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2TB02351B"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2011.03.014"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.138889"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.22711"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2013.02.006"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbon.2007.08.035"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2010.01.017"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c10812"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201900683"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm2664"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201915350"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.07.038"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4789"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308201204"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201704876"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.2138\/rmg.2006.64.8"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.115547"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1153529"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2fd20062g"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-021-00147-z"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201610554"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201200953"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2490"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colcom.2022.100649"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2013.12.041"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05124-y"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijhydene.2021.10.255"},{"key":"e_1_2_7_60_1","first-page":"147","volume":"87","author":"Li M.","year":"2023","journal-title":"Nano Res."},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1179\/026708304225019740"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CP05975B"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.9b00773"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(01)00224-6"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.4017"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300100"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202303488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T14:02:23Z","timestamp":1759759343000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202303488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,5]]},"references-count":66,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/adhm.202303488"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202303488","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,5]]},"assertion":[{"value":"2023-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2303488"}}