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While blood glucose monitoring has been the primary method of managing diabetes for decades, the increasing global prevalence of the disease suggests that there might be a need to identify additional biomarkers for a more precise early diagnosis. Herein, a microneedle patch based wearable sensor is developed for the purpose of diabetic diagnosis. Utilizing methacrylic acid modified gelatin and polyvinyl alcohol in the fabrication of microneedles\u00a0has improved their mechanical properties for skin penetration and increased swelling capacity for interstitial\u00a0fluid extraction, thanks to the double crosslinking mechanism. The fabricated microneedles are further integrated with test paper functionalized with enzyme and dye molecules to detect multiple signature biomarkers of diabetes in vivo through a colorimetric reaction. Such a wearable microneedle patch \u00a0holds significant promise for the real\u2010time monitoring of various biomarkers related to chronic diseases and aging.<\/jats:p>","DOI":"10.1002\/adhm.202303511","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T06:36:40Z","timestamp":1707892600000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Wearable Microneedle Patch for Colorimetric Detection of Multiple Signature Biomarkers in vivo Toward Diabetic Diagnosis"],"prefix":"10.1002","volume":"13","author":[{"given":"Ziting","family":"Bao","sequence":"first","affiliation":[{"name":"CUHK(SZ)\u2010Boyalife Joint Laboratory for Regenerative Medicine Engineering School of Medicine The Chinese University of Hong Kong  Shenzhen 518172 China"},{"name":"Ciechanover Institute of Precision and Regenerative Medicine School of Medicine The Chinese University of Hong Kong  Shenzhen 518172 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Lu","sequence":"additional","affiliation":[{"name":"CUHK(SZ)\u2010Boyalife Joint Laboratory for Regenerative Medicine Engineering School of Medicine The Chinese University of Hong Kong  Shenzhen 518172 China"},{"name":"Ciechanover Institute of Precision and Regenerative Medicine School of Medicine The Chinese University of Hong Kong  Shenzhen 518172 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Zhang","sequence":"additional","affiliation":[{"name":"CUHK(SZ)\u2010Boyalife Joint Laboratory for Regenerative Medicine Engineering School of Medicine The Chinese University of Hong Kong  Shenzhen 518172 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Ciechanover Institute of Precision and Regenerative Medicine School of Medicine The Chinese University of Hong Kong  Shenzhen 518172 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5118-0169","authenticated-orcid":false,"given":"Xiaolin","family":"Cui","sequence":"additional","affiliation":[{"name":"CUHK(SZ)\u2010Boyalife Joint Laboratory for Regenerative Medicine Engineering School of Medicine The Chinese University of Hong Kong  Shenzhen 518172 China"},{"name":"Ciechanover Institute of Precision and Regenerative Medicine School of Medicine The Chinese University of Hong Kong  Shenzhen 518172 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhen","family":"Liu","sequence":"additional","affiliation":[{"name":"CUHK(SZ)\u2010Boyalife Joint Laboratory for Regenerative Medicine Engineering School of Medicine The Chinese University of Hong Kong  Shenzhen 518172 China"},{"name":"Ciechanover Institute of Precision and Regenerative Medicine School of Medicine The Chinese University of Hong Kong  Shenzhen 518172 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,17]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/L20-0011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12804"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.173"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2017.09.009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2022.114029"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2022.114251"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA04975C"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.752514"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.2c00854"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s592-001-8075-9"},{"key":"e_1_2_8_12_1","first-page":"1490","volume":"11","author":"Higashiura Y.","year":"2020","journal-title":"J. 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