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It is challenging to develop an antibiotic\u2010free bactericidal and osteogenic\u2010enhanced strategy for IAOM. Herein, an IAOM\u2010tailored antibacterial and osteoinductive composite of copper (Cu)\u2013strontium (Sr) peroxide nanoparticles (CSp NPs), encapsulated in polyethylene glycol diacrylate (PEGDA) (CSp@PEGDA), is designed. The dual functional CSp NPs display hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>) self\u2010supplying and Fenton catalytic Cu<jats:sup>2+<\/jats:sup> ions\u2019 release, generating plenty of hydroxyl radical (<jats:sup>\u2022<\/jats:sup>OH) in a pH\u2010responsive manner for bacterial killing, while the released Sr<jats:sup>2+<\/jats:sup> promotes the in vitro osteogenicity regarding cell proliferation, alkaline phosphatase activity, extracellular matrix calcification, and osteo\u2010associated genes expression. The integration of Cu<jats:sup>2+<\/jats:sup> and Sr<jats:sup>2+<\/jats:sup> in CSp NPs together with the coated PEGDA hydrogel ensures the stable and sustainable ion release during short\u2010 and long\u2010term periods. Benefitted from the injectablity and photo\u2010crosslink ability, CSp@PEGDA is able to thoroughly fill the infectious site and gelate in situ for bacterial elimination and bone regeneration, which is verified through in vivo evaluation using a clinical\u2010simulating IAOM mouse model. These favorable abilities of CSp@PEGDA precisely meet the multiple therapeutic needs and pave a promising way for implant\u2010associated osteomyelitis treatment.<\/jats:p>","DOI":"10.1002\/adhm.202303529","type":"journal-article","created":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T04:29:21Z","timestamp":1709353761000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Remodeling Microenvironment for Implant\u2010Associated Osteomyelitis by Dual Metal Peroxide"],"prefix":"10.1002","volume":"13","author":[{"given":"Xin","family":"Guan","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine Nanfang Hospital Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Bone and 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