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In response to the lack of in situ retention and pro\u2010wound healing properties of existing anti\u2010adhesion barriers, this work reports an injectable adhesive\u2010antifouling bifunctional hydrogel (AAB\u2010hydrogel). This AAB\u2010hydrogel can be constructed by \u201ctwo\u2010step\u201d injection. The tissue adhesive hydrogel based on gallic acid\u2010modified chitosan and aldehyde\u2010modified dextran is prepared as the bottom hydrogel (B\u2010hydrogel) by Schiff base reaction. The aldehyde\u2010modified zwitterionic dextran\/carboxymethyl chitosan\u2010based hydrogel is formed on the B\u2010hydrogel surface as the antifouling top hydrogel (T\u2010hydrogel). The AAB\u2010hydrogel exhibits good bilayer binding and asymmetric properties, including tissue adhesive, antifouling, and antimicrobial properties. To evaluate the anti\u2010adhesion effect in vivo, the prepared hydrogels are injected onto the wound surface of a mouse abdominal wall abrasion\u2010cecum defect model. Results suggest that the AAB\u2010hydrogel has antioxidant capacity and can reduce the postoperative inflammatory response by modulating the macrophage phenotype. Moreover, the AAB\u2010hydrogel could effectively inhibit the formation of postoperative adhesions by reducing protein deposition, and resisting fibroblast adhesions and bacteria attacking. Therefore, AAB\u2010hydrogel is a promising candidate for the prevention of postoperative peritoneal adhesions.<\/jats:p>","DOI":"10.1002\/adhm.202303574","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:57:37Z","timestamp":1703033857000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Injectable Asymmetric Adhesive\u2010Antifouling Bifunctional Hydrogel for Peritoneal Adhesion Prevention"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0160-8571","authenticated-orcid":false,"given":"Zhongming","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Chemical Engineering and Technology Tianjin University  Tianjin 300072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences North China University of Science 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