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Current pulp capping agents have restricted effects in the infectious and inflammatory microenvironment. To address this, a multifunctional hydrogel (TGH\/DM) with antibacterial, immunomodulatory, and mineralization\u2010promoting effects is designed. The antimicrobial peptide (AMP) and demineralized dentin matrix are incorporated into the hydrogel, achieving sustainable delivery of AMP and a cocktail of growth factors. In vitro results show that TGH\/DM could kill endodontic microbiota, ameliorate inflammatory responses of human dental pulp stem cells (hDPSCs), and prompt odontogenic differentiation of inflammatory hDPSCs via activation of peroxisome proliferator\u2010activated receptor gamma. In vivo results suggest that TGH\/DM is capable of inducing M2 phenotype transformation of macrophages in mice and fostering the regeneration of the dentin\u2010pulp complex in inflamed pulps of beagle dogs. Overall, this study first proposes the synergistic regulation of AMP and tissue\u2010specific extracellular matrix for the treatment of pulpitis, and the advanced hydrogel provides a facile and effective way for VPT.<\/jats:p>","DOI":"10.1002\/adhm.202303709","type":"journal-article","created":{"date-parts":[[2024,3,3]],"date-time":"2024-03-03T01:18:48Z","timestamp":1709428728000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Antimicrobial Peptide\u2010 and Dentin Matrix\u2010Functionalized Hydrogel for Vital Pulp Therapy via Synergistic Bacteriostasis, Immunomodulation, and Dentinogenesis"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7021-5818","authenticated-orcid":false,"given":"Zhuo","family":"Xie","sequence":"first","affiliation":[{"name":"Hospital of Stomatology Guanghua School of Stomatology Sun Yat\u2010sen University Guangdong Provincial Key Laboratory of Stomatology Guangzhou Guangdong 510055 P. 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