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Therefore, targeting the GA to precisely destroy its proteins through local heat could induce apoptosis, offering a potential avenue for effective cancer therapy. Herein, a GA\u2010targeted photothermal agent based on protein anchoring is introduced for enhanced photothermal therapy of tumor through the modification of near\u2010infrared molecular dye with maleimide derivative and benzene sulfonamide. The photothermal agent can actively target the GA and covalently anchor to its sulfhydryl proteins, thereby increasing its retention within the GA. Under laser irradiation, the heat generated by the photothermal agent efficiently disrupts sulfhydryl proteins in situ, leading to GA dysfunction and ultimately inducing cell apoptosis. In vivo experiments demonstrate that the photothermal agent can precisely treat tumors and significantly reduce side effects.<\/jats:p>","DOI":"10.1002\/adhm.202303749","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T05:54:35Z","timestamp":1710395675000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A Golgi Apparatus\u2010Targeted Photothermal Agent with Protein Anchoring for Enhanced Cancer Photothermal Therapy"],"prefix":"10.1002","volume":"13","author":[{"given":"Mingwan","family":"Shi","sequence":"first","affiliation":[{"name":"College of Chemistry Chemical Engineering and Materials Science Key Laboratory of Molecular and Nano Probes Ministry of Education Institute of Molecular and Nano Science Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong  Jinan 250014 P. R. 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