{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:05:52Z","timestamp":1791655552454,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T00:00:00Z","timestamp":1709942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204326"],"award-info":[{"award-number":["82204326"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52073293"],"award-info":[{"award-number":["52073293"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31971303"],"award-info":[{"award-number":["31971303"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52273160"],"award-info":[{"award-number":["52273160"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Short\u2010chain antifungal peptides (AFPs) inspired by histatin 5 have been designed to address the problem of antifungal drug resistance. These AFPs demonstrate remarkable antifungal activity, with a minimal inhibitory concentration as low as 2\u00a0\u00b5g mL<jats:sup>\u22121<\/jats:sup>. Notably, these AFPs display a strong preference for targeting fungi rather than bacteria and mammalian cells. This is achieved by binding the histidine\u2010rich domains of the AFPs to the Ssa1\/2 proteins in the fungal cell wall, as well as the reduced membrane\u2010disrupting activity due to their low amphiphilicity. These peptides disrupt the nucleus and mitochondria once inside the cells, leading to reactive oxygen species production and cell damage. In a mouse model of vulvovaginal candidiasis, the AFPs demonstrate not only antifungal activity, but also promote the growth of beneficial <jats:italic>Lactobacillus<\/jats:italic> spp. This research provides valuable insights for the development of fungus\u2010specific AFPs and offers a promising strategy for the treatment of fungal infectious diseases.<\/jats:p>","DOI":"10.1002\/adhm.202303755","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T23:28:55Z","timestamp":1709249335000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Histatin 5\u2010Inspired Short\u2010Chain Peptides Selectively Combating Pathogenic Fungi with Multifaceted Mechanisms"],"prefix":"10.1002","volume":"13","author":[{"given":"Guojun","family":"Lu","sequence":"first","affiliation":[{"name":"Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences  No. 29, Zhongguancun East Road Beijing 100190 P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Ju","sequence":"additional","affiliation":[{"name":"Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences  No. 29, Zhongguancun East Road Beijing 100190 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6722-0487","authenticated-orcid":false,"given":"Meng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences  No. 29, Zhongguancun East Road Beijing 100190 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhao","family":"Ou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences  No. 29, Zhongguancun East Road Beijing 100190 P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences  No. 29, Zhongguancun East Road Beijing 100190 P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejia","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences  No. 29, Zhongguancun East Road Beijing 100190 P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences  No. 29, Zhongguancun East Road Beijing 100190 P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxiao","family":"Wan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences  No. 29, Zhongguancun East Road Beijing 100190 P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4607-2785","authenticated-orcid":false,"given":"Ye","family":"Tian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences  No. 29, Zhongguancun East Road Beijing 100190 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6119-3227","authenticated-orcid":false,"given":"Zhongwei","family":"Niu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences  No. 29, Zhongguancun East Road Beijing 100190 P. R. China"},{"name":"School of Future Technology University of Chinese Academy of Sciences  Beijing 100049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,9]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aap7999"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004404"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd6919"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00199"},{"key":"e_1_2_8_3_1","volume-title":"WHO Fungal Priority Pathogens List to Guide Research, Development and Public Health Action","year":"2022"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01670-13"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b19927"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0058-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00095-14"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150196"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2003.020"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01729"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.08.043"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CS00556K"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202111066"},{"key":"e_1_2_8_11_1","volume-title":"CLSI Supplement M100","author":"CLSI","year":"2020"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.1c00408"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.2558"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1139\/o98-066"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.8b01281"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M604064200"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja051648k"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.2.348-354.2000"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2003526117"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202200778"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201809410"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2023.106524"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00072a004"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-015-7265-y"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202205781"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202104871"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26221-y"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202000505"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09674"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.157"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2175"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg0949"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30103-8"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/1040841X.2011.576332"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp053720"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-022-01083-2"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01264"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-021-00530-8"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-023-10050-0"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00624-20"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202303755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:18:07Z","timestamp":1759774687000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202303755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,9]]},"references-count":45,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/adhm.202303755"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202303755","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,9]]},"assertion":[{"value":"2023-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2303755"}}