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This clinical conundrum poses three challenges for local drug delivery systems: stable and continuous delivery, good biocompatibility, and the ability to package new targeted drugs that can synergize with other treatments. Here, a drug\u2010laden hydrogel generated from pure DNA strands and highly programmable in adjusting its mesh size is reported. Meanwhile, the DNA hydrogel can assist the microcrystallization of novel radiosensitizing drugs, ataxia telangiectasia and rad3\u2010related protein (ATR) inhibitor (Elimusertib), further facilitating its long\u2010term release. When applied to the tumor site, the hydrogel system demonstrates significant antitumor activity, minimized systemic toxicity, and has a modulatory effect on the tumor\u2010immune cell interface. This drug\u2010loaded DNA\u2010hydrogel platform represents a novel modality for adjuvant therapy in patients with surgical residual tumor lesions and lymph node metastasis.<\/jats:p>","DOI":"10.1002\/adhm.202303762","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T09:48:30Z","timestamp":1701683310000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Programmable DNA Hydrogel Assisting Microcrystal Formulations for Sustained Locoregional Drug Delivery in Surgical Residual Tumor Lesions and Lymph Node Metastasis"],"prefix":"10.1002","volume":"13","author":[{"given":"Zi\u2010jie","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Liver Surgery Renji Hospital School of Medicine Shanghai Jiao Tong University  Shanghai 200127 China"},{"name":"Shanghai Institute of Transplantation  Shanghai 200127 China"},{"name":"Shanghai Engineering Research Center of 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