{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:54:01Z","timestamp":1792788841061,"version":"4.5.0"},"reference-count":63,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2020202002"],"award-info":[{"award-number":["H2020202002"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral nerve regeneration and functional recovery rely on the chemical, physical, and structural properties of nerve guidance conduits (NGCs). However, the limited support for long\u2010distance nerve regeneration and axonal guidance has hindered the widespread use of NGCs. This study introduces a novel nerve guidance conduit with oriented lateral walls, incorporating multi\u2010walled carbon nanotubes (MWCNTs) within core\u2010shell fibers prepared in a single step using a modified electrohydrodynamic (EHD) printing technique to promote peripheral nerve regeneration. The structured conduit demonstrated exceptional stability, mechanical properties, and biocompatibility, significantly enhancing the functionality of NGCs. In vitro cell studies revealed that RSC96 cells adhered and proliferated effectively along the oriented fibers, demonstrating a favorable response to the distinctive architectures and properties. Subsequently, a rat sciatic nerve injury model demonstrated effective efficacy in promoting peripheral nerve regeneration and functional recovery. Tissue analysis and functional testing highlighted the significant impact of MWCNT concentration in enhancing peripheral nerve regeneration and confirming well\u2010matured aligned axonal growth, muscle recovery, and higher densities of myelinated axons. These findings demonstrate the potential of oriented lateral architectures with coaxial MWCNT fibers as a promising approach to support long\u2010distance regeneration and encourage directional nerve growth for peripheral nerve repair in clinical applications.<\/jats:p>","DOI":"10.1002\/adhm.202303867","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T02:55:12Z","timestamp":1705978512000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Leveraging Oriented Lateral Walls of Nerve Guidance Conduit with Core\u2013Shell MWCNTs Fibers for Peripheral Nerve Regeneration"],"prefix":"10.1002","volume":"13","author":[{"given":"Renyuan","family":"Sun","sequence":"first","affiliation":[{"name":"State Key Laboratory of Reliability and Intelligence of Electrical Equipment Tianjin Key Laboratory of Bio\u2010Electromagnetic and Neural Engineering Hebei Key Laboratory of Bioelectromagnetics and Neuroengineering School of Health Sciences and Biomedical Engineering Hebei University of Technology  Tianjin 300132 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuna","family":"Lang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reliability and Intelligence of Electrical Equipment Tianjin Key Laboratory of Bio\u2010Electromagnetic and Neural Engineering Hebei Key Laboratory of Bioelectromagnetics and Neuroengineering School of Health Sciences and Biomedical Engineering Hebei University of Technology  Tianjin 300132 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0137-8895","authenticated-orcid":false,"given":"Ming\u2010Wei","family":"Chang","sequence":"additional","affiliation":[{"name":"Nanotechnology and Integrated Bioengineering Centre University of Ulster  Belfast BT15 1AP UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingkang","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reliability and Intelligence of Electrical Equipment Tianjin Key Laboratory of Bio\u2010Electromagnetic and Neural Engineering Hebei Key Laboratory of Bioelectromagnetics and Neuroengineering School of Health Sciences and Biomedical Engineering Hebei University of Technology  Tianjin 300132 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reliability and Intelligence of Electrical Equipment Tianjin Key Laboratory of Bio\u2010Electromagnetic and Neural Engineering Hebei Key Laboratory of Bioelectromagnetics and Neuroengineering School of Health Sciences and Biomedical Engineering Hebei University of Technology  Tianjin 300132 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiheng","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reliability and Intelligence of Electrical Equipment Tianjin Key Laboratory of Bio\u2010Electromagnetic and Neural Engineering Hebei Key Laboratory of Bioelectromagnetics and Neuroengineering School of Health Sciences and Biomedical Engineering Hebei University of Technology  Tianjin 300132 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6170-5843","authenticated-orcid":false,"given":"Baolin","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reliability and Intelligence of Electrical Equipment Tianjin Key Laboratory of Bio\u2010Electromagnetic and Neural Engineering Hebei Key Laboratory of Bioelectromagnetics and Neuroengineering School of Health Sciences and Biomedical Engineering Hebei University of Technology  Tianjin 300132 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav7753"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.131826"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bioeng.5.011303.120731"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.9b00203"},{"key":"e_1_2_8_2_3","first-page":"13","volume":"52","author":"Qi F. W.","year":"2022","journal-title":"Addit. Manuf."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-018-0001-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.139424"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2009.06.016"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c01996"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.08.052"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120108"},{"key":"e_1_2_8_8_1","first-page":"14","volume":"7","author":"Li G. C.","year":"2021","journal-title":"Sci. Adv."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2018.04.001"},{"key":"e_1_2_8_10_1","volume-title":"Annual Review of Biomedical Engineering","author":"Hoffman\u2010Kim D.","year":"2010"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/am509227t"},{"key":"e_1_2_8_11_1","first-page":"16","volume":"31","author":"Li Y.","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.02.003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00593"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.10.040"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.08.027"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtadv.2022.100325"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.08.014"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.09.030"},{"key":"e_1_2_8_19_1","first-page":"9","volume":"31","author":"Zhu X. Y.","year":"2019","journal-title":"Adv. Mater."},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addma.2022.103035"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.112185"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsmaterialslett.2c00698"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.11.010"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201002692"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1060928"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.11.042"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201500864"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2019.04.003"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.05.034"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00008"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.12.031"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118926"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00275"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201301519"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3606"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40820-021-00748-7"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmapro.2013.10.003"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00065-3"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbon.2019.07.030"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csite.2023.102951"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn3047378"},{"key":"e_1_2_8_34_1","first-page":"8","volume":"225","author":"Shi Z. Q.","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compscitech.2010.12.020"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2011.0240"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2018.11.044"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.desal.2012.11.037"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13204-021-01961-x"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.desal.2011.10.039"},{"key":"e_1_2_8_40_1","first-page":"10","volume":"9","author":"He J. K.","year":"2017","journal-title":"Biofabrication"},{"key":"e_1_2_8_41_1","first-page":"12","volume":"9","author":"Hu X. F.","year":"2020","journal-title":"Adv. Healthcare Mater."},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.01.042"},{"key":"e_1_2_8_43_1","first-page":"10","volume":"27","author":"Zhang H.","year":"2022","journal-title":"Appl. Mater. Today"},{"key":"e_1_2_8_44_1","first-page":"14","volume":"30","author":"Park J.","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100427"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c11627"},{"key":"e_1_2_8_47_1","first-page":"12","volume":"30","author":"Chen X.","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"e_1_2_8_48_1","first-page":"15","volume":"6","author":"Wang L.","year":"2020","journal-title":"Sci. Adv."},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.05.056"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202303867","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:08:12Z","timestamp":1759781292000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202303867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,15]]},"references-count":63,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/adhm.202303867"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202303867","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,15]]},"assertion":[{"value":"2023-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2303867"}}