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Neural progenitor cell (NPC) transplantation is a promising treatment option, and the identification of novel biomaterial scaffolds that support NPC engraftment and therapeutic activity is a top research priority. The objective of this study is to evaluate in situ assembled poly (ethylene glycol) (PEG)\u2010based granular hydrogels for NPC delivery in a murine model of SCI. Microgel precursors are synthesized by using thiol\u2010norbornene click chemistry to react four\u2010armed PEG\u2010amide\u2010norbornene with enzymatically degradable and cell adhesive peptides. Unreacted norbornene groups are utilized for in situ assembly into scaffolds using a PEG\u2010di\u2010tetrazine linker. The granular hydrogel scaffolds exhibit good biocompatibility and do not adversely affect the inflammatory response after SCI. 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