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Cell chirality plays a significant role in the arrangement of organs in the body as well as in the orientation of organelles, cytoskeletons, and cells. Vascular networks within the endometrium, the mucosal inner lining of the uterus, commonly display spiral architectures that rapidly form across the menstrual cycle. Herein, the role of endometrial\u2010relevant extracellular matrix stiffness, composition, and soluble signals on endometrial endothelial cell chirality is systematically examined using a high\u2010throughput microarray. Endometrial endothelial cells display marked patterns of chirality as individual cells and as cohorts in response to substrate stiffness and environmental cues. Vascular networks formed from endometrial endothelial cells also display shifts in chirality as a function of exogenous hormones. Changes in cellular\u2010scale chirality correlate with changes in vascular network parameters, suggesting a critical role for cellular chirality in directing endometrial vessel network organization.<\/jats:p>","DOI":"10.1002\/adhm.202303928","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T02:40:00Z","timestamp":1706668800000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cell Chirality of Micropatterned Endometrial Microvascular Endothelial Cells"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2674-9541","authenticated-orcid":false,"given":"Samantha G.","family":"Zambuto","sequence":"first","affiliation":[{"name":"Dept. of Bioengineering University of Illinois Urbana\u2010Champaign  Urbana IL 61801 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishita","family":"Jain","sequence":"additional","affiliation":[{"name":"Dept. of Bioengineering University of Illinois Urbana\u2010Champaign  Urbana IL 61801 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah S.","family":"Theriault","sequence":"additional","affiliation":[{"name":"Dept. of Bioengineering University of Illinois Urbana\u2010Champaign  Urbana IL 61801 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory H.","family":"Underhill","sequence":"additional","affiliation":[{"name":"Dept. of Bioengineering University of Illinois Urbana\u2010Champaign  Urbana IL 61801 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5458-154X","authenticated-orcid":false,"given":"Brendan A.C.","family":"Harley","sequence":"additional","affiliation":[{"name":"Dept. 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