{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T04:13:13Z","timestamp":1776053593069,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1904135"],"award-info":[{"award-number":["U1904135"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Early detection of renal fibrosis (RF) is very important given that it is irreversible when it progresses to the terminal stage. A key marker of RF pathogenesis is activation of myomyofibroblasts, and its targeted imaging may be a promising approach for early detection of RF, but no study has directly imaged activation of renal myomyofibroblasts. Cu<jats:sup>2+<\/jats:sup> plays a major role in the fibrotic activity of myofibroblasts. Herein, inspired by that Cu<jats:sup>2+<\/jats:sup> can complex with bovine serum albumin (BSA), BSA\u2010Ag<jats:sub>2<\/jats:sub>S quantum dots (QDs) with aggregation\u2010induced emission (AIE) property are synthesized. Then BSA\u2010Ag<jats:sub>2<\/jats:sub>S QDs are modified by chitosan (CS) with renal targeting and hyaluronic acid (HA) with myofibroblast targeting to obtain the AIE assay system (QDs@CS@HA). The system is simple to synthesize, and produces a rapid NIR fluorescence signal turn\u2010on response and a low detection limit of 75\u00a0\u00d7 10<jats:sup>\u22129<\/jats:sup> <jats:sc>m<\/jats:sc> to Cu<jats:sup>2+<\/jats:sup>. In addition, cellular and animal experiments have shown that QDs@CS@HA has good biosafety and cell\u2010targeted imaging capability for RF. Based on the successful application of QDs@CS@HA and the mechanism of RF progression in early RF detection, it is expected that QDs@CS@HA may detect RF before the appearance of clinical symptoms.<\/jats:p>","DOI":"10.1002\/adhm.202303944","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T01:55:25Z","timestamp":1709690125000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["An AIE Controlled \u201cOff\u2010On\u201d Cu<sup>2+<\/sup>\u2010Sensitive Probe for Early Detection of Renal Fibrosis"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9978-0702","authenticated-orcid":false,"given":"Jie","family":"Zhou","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Zhengzhou University  Zhengzhou 450001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fusui","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Zhengzhou University  Zhengzhou 450001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomeng","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Zhengzhou University  Zhengzhou 450001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huili","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Zhengzhou University  Zhengzhou 450001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Guan","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Zhengzhou University  Zhengzhou 450001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Zhengzhou University  Zhengzhou 450001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwen","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Zhengzhou University  Zhengzhou 450001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junfen","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Zhengzhou University  Zhengzhou 450001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat4865"},{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-021-05343-x"},{"key":"e_1_2_9_1_3","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e31827a4990"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000476"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.11152\/mu.2013.2066.183.per"},{"key":"e_1_2_9_4_1","first-page":"50","volume":"34","author":"Yan D.","year":"2022","journal-title":"Adv. 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