{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T12:34:05Z","timestamp":1791722045525,"version":"4.3.4"},"reference-count":105,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T00:00:00Z","timestamp":1706227200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T00:00:00Z","timestamp":1706227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP210101862"],"award-info":[{"award-number":["DP210101862"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010248","name":"Zhejiang Province Public Welfare Technology Application Research Project","doi-asserted-by":"publisher","award":["LGF22H140008"],"award-info":[{"award-number":["LGF22H140008"]}],"id":[{"id":"10.13039\/501100010248","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52105303"],"award-info":[{"award-number":["52105303"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["20220101209JC"],"award-info":[{"award-number":["20220101209JC"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Magnesium (Mg) alloys are widely used in bone fixation and bone repair as biodegradable bone\u2010implant materials. However, their clinical application is limited due to their fast corrosion rate and poor mechanical stability. Here, the development of Mg\u20132Zn\u20130.5Ca\u20130.5Sr (MZCS) and Mg\u20132Zn\u20130.5Ca\u20130.5Zr (MZCZ) alloys with improved mechanical properties, corrosion resistance, cytocompatibility, osteogenesis performance, and antibacterial capability is reported. The hot\u2010extruded (HE) MZCZ sample exhibits the highest ultimate tensile strength of 255.8 \u00b1 2.4\u00a0MPa and the highest yield strength of 208.4 \u00b1 2.8\u00a0MPa and an elongation of 15.7 \u00b1 0.5%. The HE MZCS sample shows the highest corrosion resistance, with the lowest corrosion current density of 0.2 \u00b1 0.1\u00a0\u00b5A cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    and the lowest corrosion rate of 4 \u00b1 2\u00a0\u00b5m per year obtained from electrochemical testing, and a degradation rate of 368\u00a0\u00b5m per year and hydrogen evolution rate of 0.83 \u00b1 0.03\u00a0mL cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    per day obtained from immersion testing. The MZCZ sample shows the highest cell viability in relation to MC3T3\u2010E1 cells among all alloy extracts, indicating good cytocompatibility except at 25% concentration. Furthermore, the MZCZ alloy shows good antibacterial capability against\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/adhm.202303975","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T08:56:45Z","timestamp":1705568205000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Enhanced Mechanical Properties, Corrosion Resistance, Cytocompatibility, Osteogenesis, and Antibacterial Performance of Biodegradable Mg\u20132Zn\u20130.5Ca\u20130.5Sr\/Zr Alloys for Bone\u2010Implant Application"],"prefix":"10.1002","volume":"13","author":[{"given":"Xian","family":"Tong","sequence":"first","affiliation":[{"name":"Institute of Stomatology School and Hospital of Stomatology Wenzhou Medical University  Wenzhou 325027 China"},{"name":"School of Materials Science and Engineering Xiangtan University  Xiangtan 411105 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilong","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics The Third Affiliated Hospital of Wenzhou Medical University (Ruian People's Hospital)  Wenzhou 325016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runqi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Oral Disease and Biomedical Sciences and Chongqing Municipal Key Laboratory of Oral Biomedical Engineering Higher Education and Stomatological Hospital Chongqing Medical University  Chongqing 401174 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinkun","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics The Third Affiliated Hospital of Wenzhou Medical University (Ruian People's Hospital)  Wenzhou 325016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuncang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Engineering RMIT University Melbourne  Victoria 3001 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bionic Engineering of Ministry of Education College of Biological and Agricultural Engineering Jilin University  Changchun 130022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Automobile Materials of Ministry of Education School of Materials Science and Engineering Jilin University  Changchun 130025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinguo","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Automobile Materials of Ministry of Education School of Materials Science and Engineering Jilin University  Changchun 130025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixing","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Stomatology School and Hospital of Stomatology Wenzhou Medical University  Wenzhou 325027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8008-3536","authenticated-orcid":false,"given":"Cuie","family":"Wen","sequence":"additional","affiliation":[{"name":"School of Engineering RMIT University Melbourne  Victoria 3001 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,26]]},"reference":[{"key":"e_1_2_8_1_1","first-page":"71","volume":"3","author":"Zamani Y.","year":"2021","journal-title":"J. Compos. Compd."},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmst.2019.07.024"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885328216657271"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acc.2015.10.002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-020-02183-y"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00012.2014"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.127616"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2019.11.001"},{"key":"e_1_2_8_9_1","volume-title":"Electrochemical Series","author":"Van\u00fdsek P.","year":"2008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmats.2021.761052"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.08.028"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.12.023"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.35023"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-019-1143-8"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/039139880502801103"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra035415"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.04.044"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11665-019-04080-5"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scriptamat.2007.01.006"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1003-6326(10)60183-5"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1003-6326(18)64676-X"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13236"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msea.2020.138929"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2020.156640"},{"key":"e_1_2_8_25_1","first-page":"209","volume-title":"Magnesium Technology","author":"Erinc M.","year":"2009"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33651"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2021.116107"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.02.018"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10853-020-04817-x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.04.028"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scriptamat.2008.02.017"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msea.2009.06.002"},{"key":"e_1_2_8_33_1","first-page":"602","volume-title":"Constitution of Binary Alloys, First Supplement","author":"Elliott R. P.","year":"1965"},{"key":"e_1_2_8_34_1","volume-title":"Standard Test Methods for Tension Testing of Metallic Materials","year":"2011"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.12.027"},{"key":"e_1_2_8_36_1","volume-title":"Standard Practice for Calculation of Corrosion Rates and Related Information from Electrochemical Measurements","year":"2015"},{"key":"e_1_2_8_37_1","volume-title":"Standard Guide for Laboratory Immersion Corrosion Testing of Metals","year":"2013"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202214657"},{"key":"e_1_2_8_39_1","volume-title":"Biological Evaluation of Medical Devices","year":"2012"},{"key":"e_1_2_8_40_1","volume-title":"Microbiology of the Food Chain \u2013 Horizontal Method for the Enumeration of Coagulase\u2010Positive Staphylococci (Staphylococcus aureus and Other Species)","year":"2021"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.10.053"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matchar.2019.109842"},{"key":"e_1_2_8_43_1","first-page":"2623","volume":"21","author":"Huan Z. G.","year":"2010","journal-title":"J. Mater. Sci."},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2017.01.178"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2016.08.164"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2017.01.005"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.05.031"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11665-016-2207-0"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2020.155611"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/21663831.2020.1759718"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msea.2019.138474"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-020-00280-6"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2018.12.109"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2013.01.089"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmrt.2022.02.035"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coco.2021.100776"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13826"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1088\/2053-1591\/ac083c"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jma.2021.10.008"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11661-999-0098-5"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msea.2016.01.056"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scriptamat.2012.09.026"},{"key":"e_1_2_8_63_1","volume-title":"Materials Science and Engineering: An Introduction","author":"Callister W. D.","year":"2018"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actamat.2006.09.010"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1080\/01418610208240050"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msea.2021.142026"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2004.08.084"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msea.2012.01.055"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smmf.2023.100014"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jma.2019.02.002"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.corsci.2014.07.015"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/adem.200600252"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.32813"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.5012\/bkcs.2009.30.10.2280"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.porgcoat.2019.04.013"},{"key":"e_1_2_8_76_1","first-page":"166","volume":"11","author":"Andrade L. M.","year":"2021","journal-title":"Bioact. Mater."},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-012-5836-7"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.corsci.2016.02.041"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2018.07.053"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.corsci.2020.108661"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.4028\/www.scientific.net\/JBBTE.12.25"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2014.05.024"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.corsci.2019.06.022"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.corsci.2019.108419"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.09.049"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.02.002"},{"key":"e_1_2_8_87_1","volume-title":"Biological Evaluation of Medical Devices","year":"2009"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/5\/4\/045005"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bej.2014.05.005"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.1.229"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2018.10.009"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2009.06.028"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma11050678"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199802)39:2<331::AID-JBM22>3.0.CO;2-E"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e3181e73f20"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951106000011"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0946-672X(01)80063-8"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(91)90161-9"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2015.2115"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2011.07.109"},{"key":"e_1_2_8_101_1","volume-title":"Textile Fabrics \u2013 Determination of Antibacterial Activity \u2013 Agar Diffusion Plate Test","year":"2004"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2011.09.031"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl052326h"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2020.110813"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1094\/ASBCJ-2014-0326-02"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202303975","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202303975","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T12:33:59Z","timestamp":1759754039000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202303975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,26]]},"references-count":105,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/adhm.202303975"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202303975","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,26]]},"assertion":[{"value":"2023-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2303975"}}