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Injectable\u2010hydrogel\u2010based tissue sealants featuring multiple actions, including fit\u2010to\u2010shape in situ gelation, rapid hemostasis, pro\u2010angiogenic, anti\u2010bacterial and outcome tracking, are ideal for the management of organ trauma wounds. Herein, an injectable\u2010hydrogel tissue sealant AN@CD\u2010PEG&amp;TQ which consists of four\u2010arm 4\u2010arm poly(ethylene glycol) (PEG\u2010SC) succinimidyl carbonate), AN@CD nanoprobe, and two bioactive peptides (anti\u2010microbial peptide Tet213 and pro\u2010angiogenic peptide QK) is developed. Among them, AN@CD nanoparticles form through host\/guest complexation of amino\u2010group\u2010containing \u03b2\u2010cyclodextrin and adamantyl group, enabling in situ biomarker (NO)\u2010activatable optoacoustic\/NIR\u2010II: Near\u2010infrared second biological window fluorescent imaging. The ample \u2500NH2 groups on the surface of AN@CD readily engage in rapid cross\u2010linking with succinimidyl ester groups located at the ends of four\u2010arm PEG\u2010SC. This cross\u2010linking expedites the gelation process without necessitating additional initiators or cross\u2010linking agents; thus, significantly enhancing both hydrogel's application convenience and biocompatibility. Bioactive peptides (Tet213 and QK) safeguard against possible bacterial infections, facilitate angiogenesis, and eventually, improve organ wounds healing. This hydrogel\u2010based tissue sealant demonstrates superior therapeutic and bioimaging performance in various mouse models including liver hemorrhage, gastric perforation, and bacterial\u2010infected skin wound mouse models, highlighting its potential as a high\u2010performance wound sealant for organ bleeding wound management.<\/jats:p>","DOI":"10.1002\/adhm.202303997","type":"journal-article","created":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T04:08:53Z","timestamp":1706414933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Injectable\u2010Hydrogel\u2010Based Tissue Sealant for Hemostasis, Bacteria Inhibition, and Pro\u2010Angiogenesis in Organ Bleeding Wounds and Therapeutic Outcome Monitoring Via NIR\u2010II Optical Imaging"],"prefix":"10.1002","volume":"13","author":[{"given":"Lihe","family":"Sun","sequence":"first","affiliation":[{"name":"Biomedical Division, State Key Laboratory of 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