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However, it is reported that PEG\u2013lipids may also contribute to accelerated blood clearance and rare cases of hypersensitivity; this highlights the utility of exploring PEG\u2013lipid alternatives. Here, it is shown that LNPs containing poly(2\u2010ethyl\u20102\u2010oxazoline) (PEOZ)\u2013lipids can deliver messenger RNA (mRNA) to multiple cell types in mice inside and outside the liver. In addition, it is reported that LNPs formulated with PEOZ\u2013lipids show reduced clearance from the bloodstream and lower levels of antistealth lipid immunoglobulin Ms than LNPs formulated with PEG\u2013lipids. These data justify further exploration of PEOZ\u2013lipids as alternatives to PEG\u2013lipids in LNP\u2013RNA formulations.<\/jats:p>","DOI":"10.1002\/adhm.202304033","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:53:51Z","timestamp":1707267231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Substituting Poly(ethylene glycol) Lipids with Poly(2\u2010ethyl\u20102\u2010oxazoline) Lipids Improves Lipid Nanoparticle Repeat Dosing"],"prefix":"10.1002","volume":"13","author":[{"given":"Alejandro J. 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