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In this work, a novel 3D scaffold with anisotropic micropores and nanotopographical patterns is developed. Scaffolds with oriented pores are fabricated via the selective extraction of water\u2010soluble polyethylene oxide from its poly(\n                    <jats:italic>\u03b5<\/jats:italic>\n                    \u2010caprolactone) co\u2010continuous mixture and uniaxial stretching. The plate apatite\u2010like lamellae are subsequently hatched on the pore walls through surface\u2010induced epitaxial crystallization. Such a unique geometric architecture yields a synergistic effect on the osteogenic capability. The prepared scaffold leads to a 19.2% and 128.0% increase in the alkaline phosphatase activity of rat bone mesenchymal stem cells compared to that of the scaffolds with only oriented pores and only nanotopographical patterns, respectively. It also induces the greatest upregulation of osteogenic\u2010related gene expression in vitro. The cranial defect repair results demonstrate that the prepared scaffold effectively promotes new bone regeneration, as indicated by a 350% increase in collagen I expression in vivo compared to the isotropic porous scaffold without surface nanotopology after implantation for 14\u00a0weeks. Overall, this work provides geometric motifs for the transduction of biophysical cues in 3D porous scaffolds, which is a promising option for tissue engineering applications.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202304178","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T02:35:07Z","timestamp":1710556507000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Hierarchically Biomimetic Scaffolds with Anisotropic Micropores and Nanotopological Patterns to Promote Bone Regeneration via Geometric Modulation"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0716-3051","authenticated-orcid":false,"given":"Xin","family":"Wei","sequence":"first","affiliation":[{"name":"College of Polymer Science and Engineering and State Key Laboratory of Polymer Materials Engineering Sichuan University  Chengdu 610065 P. R. 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