{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T06:16:37Z","timestamp":1791699397316,"version":"4.3.4"},"reference-count":65,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2023NSFSC1548"],"award-info":[{"award-number":["2023NSFSC1548"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103767"],"award-info":[{"award-number":["82103767"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The systemic use of tranexamic acid (TA) as an oral drug can bring adverse reactions, while intradermal injection leads to pain and a risk of infection. Moreover, it is difficult for highly hydrophilic TA to penetrate the skin barrier that contains lots of hydrophobic lipid compounds, which poses enormous restrictions on its topical application. Current transdermal TA delivery strategies are suffering from low drug load rates, plus their synthesis complexity, time\u2010consumption, etc. adding to the difficulty of TA topical application in clinical therapeutics. To increase the penetration of TA, a novel approach using TA\u2010loaded ZIF\u20108 (TA@ZIF\u20108) is developed. The encapsulation efficiency of TA@ZIF\u20108 reaches \u224825% through physical adsorption and chemical bonding of TA indicates by theoretical simulation and the improved TA penetration is elevated through activating the aquaporin\u20103 (AQP\u20103) protein. Additionally, in vivo and in vitro experiments demonstrate the preponderance of TA@ZIF\u20108 for penetration ability and the advantages in intracellular uptake, minor cytotoxicity, and inhibition of melanogenesis and inflammatory factors. Moreover, clinical trials demonstrate the safety and efficacy of TA@ZIF\u20108 in the treatment of melasma and rosacea. This work presents a potential topical application of TA, free from the safety concerns associated with systemic drug administration.<\/jats:p>","DOI":"10.1002\/adhm.202304189","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:29:46Z","timestamp":1711585786000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Enhancing Tranexamic Acid Penetration through AQP\u20103 Protein Triggering via ZIF\u20108 Encapsulation for Melasma and Rosacea Therapy"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9777-0535","authenticated-orcid":false,"given":"Jie","family":"Tang","sequence":"first","affiliation":[{"name":"Cosmetics Safety and Efficacy Evaluation Center West China Hospital Sichuan University  Chengdu 610041 China"},{"name":"NMPA Key Laboratory for Human Evaluation and Big Data of Cosmetics Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Hu","sequence":"additional","affiliation":[{"name":"West China School of Basic Medical Sciences &amp; Forensic Medicine Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hua","sequence":"additional","affiliation":[{"name":"Cosmetics Safety and Efficacy Evaluation Center West China Hospital Sichuan University  Chengdu 610041 China"},{"name":"NMPA Key Laboratory for Human Evaluation and Big Data of Cosmetics Sichuan University  Chengdu 610041 China"},{"name":"Department of Dermatology West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoning","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Environment Southwest Minzu University  Chengdu 610225 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Cosmetics Safety and Efficacy Evaluation Center West China Hospital Sichuan University  Chengdu 610041 China"},{"name":"NMPA Key Laboratory for Human Evaluation and Big Data of Cosmetics Sichuan University  Chengdu 610041 China"},{"name":"Department of Dermatology West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8797-4788","authenticated-orcid":false,"given":"Fujian","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Environment Southwest Minzu University  Chengdu 610225 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12910"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.12.031"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.09.053"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23135"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-016-8585-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.12.067"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.09.074"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060824"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.05.009"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.164415"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2018.12.008"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03251.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05305.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16598"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001518"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00595-7"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.08.049"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18420"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16160"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(01)00980-2"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.09.053"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2018.3494"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.09.053"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2015.09.004"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.115744"},{"key":"e_1_2_8_26_1","first-page":"373","volume":"17","author":"Sun Z.","year":"2020","journal-title":"Mol. Pharmaceut."},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.04.031"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40820-020-00423-3"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c15673"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8240"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.1c00178"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.0c05432"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201602335"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200601878"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2021.0061"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2019.07.007"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2018.07.099"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202000105"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2018.07.099"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.6b01208"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micromeso.2021.110885"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00103"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201802830"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2021.05.001"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.69999"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c06874"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00075.2020"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.12.006"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22083970"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.297"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.237"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.1c00502"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201905724"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9060624"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.11.008"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12576-017-0571-7"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.1006"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10716.x"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21842"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp952713n"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.77.3865"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20495"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevB.66.155125"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevB.16.1746"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.12.067"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202304189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:18:41Z","timestamp":1759774721000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202304189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,24]]},"references-count":65,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/adhm.202304189"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202304189","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,24]]},"assertion":[{"value":"2023-11-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2304189"}}