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Contemporary therapeutic approaches predominantly focus on the amelioration of symptoms rather than addressing the fundamental etiological factors. Oxidative stress is a notable feature and an important mediator of IR damage. Lycium barbarum polysaccharide (LBP), the main active ingredient of Lycium barbarum, has various pharmacological effects, including antioxidation, immunoregulation, and neuroprotective effects. In this study, the ROS\u2010consumable moiety phenylboronic acid pinacol ester (PBA) is introduced to LBP molecules, which can self\u2010assemble into nanoparticles in aqueous solution. This nanoparticle (termed PLBP) can reduce the cellular ROS levels and enhance the antioxidant capability of RGCs by activating the NRF2 pathway, thus protecting RGCs from ferroptosis and preserving visual function in response to IR injury. PLBP also reduces neuroinflammation by inhibiting the ability of microglia to phagocytose, migrate, secrete inflammatory cytokines, and activate the NF\u2010\u03baB pathway. In conclusion, this approach can be used as an inspiration for the future development of neuroprotective drugs.<\/jats:p>","DOI":"10.1002\/adhm.202304285","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T05:48:56Z","timestamp":1720763336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Lycium Barbarum Polysaccharide\u2010Derived Nanoparticles Protect Visual Function by Inhibiting RGC Ferroptosis and Microglial Activation in Retinal Ischemia\u2012Reperfusion Mice"],"prefix":"10.1002","volume":"13","author":[{"given":"Yueqi","family":"Ni","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology 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