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Here, an electrochemical DNA biosensor based on polyamide\/polyaniline carbon nanotubes (PA\/PANI\u2010CNTs) is developed with the aim of diagnosing AD early using a simple, low\u2010cost, and accessible method to rapidly detect A\u03b242 in human blood. Electrospun PA nanofibers served as the skeleton for the successive in situ deposition of PANI and CNTs, which contribute both high conductivity and abundant binding sites for the A\u03b242 aptamers. After the aptamers are immobilized, this aptasensor exhibits precise and specific detection of A\u03b242 in human blood within only 4\u00a0min with an extremely fast response rate, lower detection limit, and excellent linear detection range. These findings make a significant contribution to advancing the development of serum\u2010based detection techniques for A\u03b242, thereby paving the way for improved diagnostic capabilities in the field of AD.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202304355","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T17:59:35Z","timestamp":1708624775000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Freestanding Nanofiber\u2010Assembled Aptasensor for Precisely and Ultrafast Electrochemical Detection of Alzheimer's Disease Biomarkers"],"prefix":"10.1002","volume":"13","author":[{"given":"Hui","family":"Liu","sequence":"first","affiliation":[{"name":"Nanjing Stomatological Hospital Affiliated Hospital of Medical School Research Institute of Stomatology Nanjing University  30 Zhongyang Road Nanjing Jiangsu 210008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueli","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Materials\u2010Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University  Nanjing 211816 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Materials\u2010Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University  Nanjing 211816 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University  321 Zhongshan Road Nanjing 210008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2537-7950","authenticated-orcid":false,"given":"Heng","family":"Dong","sequence":"additional","affiliation":[{"name":"Nanjing Stomatological Hospital Affiliated Hospital of Medical School Research Institute of Stomatology Nanjing University  30 Zhongyang Road Nanjing Jiangsu 210008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6337-3101","authenticated-orcid":false,"given":"Zhenyu","family":"Chu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Materials\u2010Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University  Nanjing 211816 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1375-y"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867327666201111141341"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00457"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.07.017"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-01117-1"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0721-9"},{"key":"e_1_2_8_5_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2018.12.004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-018-1292-6"},{"key":"e_1_2_8_6_2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.14283\/jpad.2018.41","volume":"6","author":"P\u00e9rez\u2010Grijalba V.","year":"2019","journal-title":"J. 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