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Small extracellular vesicles (sEVs) secreted by urine\u2010derived stem cells (USC\u2010sEVs) strongly promote vascular regeneration. In this study, it is aimed to explore whether USC\u2010sEVs promote the repair of CS defects. To prolong the in vivo effects of USC\u2010sEVs, a void\u2010forming photoinduced imine crosslinking hydrogel (vHG) is prepared and mixed with the USC\u2010sEV suspension. vHG encapsulated with USC\u2010sEVs (vHG\u2010sEVs) is used to repair a CS defect with length of 1.5\u00a0cm and width of 0.8\u00a0cm. The results show that vHG\u2010sEVs promote the regeneration and repair of CS defects. Histological analysis reveals abundant sinusoid\u2010like vascular structures in the vHG\u2010sEV group. Photoacoustic microscopy indicates that blood flow and microvascular structure of the defect area in the vHG\u2010sEV group are similar to those in the normal CS group. This study confirms that the in situ\u2010formed vHG\u2010sEV patch appears to be a valid and promising strategy for repairing CS defects.<\/jats:p>","DOI":"10.1002\/adhm.202304387","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T05:14:42Z","timestamp":1721625282000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Porous Photocrosslinkable Hydrogel Functionalized with USC Derived Small Extracellular Vesicles for Corpus Spongiosum Repair"],"prefix":"10.1002","volume":"13","author":[{"given":"Lin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Urology Shanghai Children's Hospital School of medicine Shanghai Jiao Tong University  Shanghai 200240 China"},{"name":"Department of Urology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai 200233 China"},{"name":"Shanghai Eastern Institute of Urologic 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