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However, most conventional ferroptosis inducers not only fail to trigger intracellular lipid peroxidation storm, but are also prone to cause ferroptosis\u2010related toxicity through off\u2010target destruction of intracellular antioxidant defense systems. Therefore, a potent and highly tumor\u2010specific ferroptosis induction modality is desired. Herein, a self\u2010cooperative nanomedicine for imaging\u2010guided photothermal ferrotherapy, which is fabricated based on molecular nanoassembly (NA) of DiR (a photothermal probe) and ferrocene (Fc, a reactant of the Fenton reaction), is elaborately exploited. DiR\u2010elicited hyperthermia induces both photothermal therapy (PTT) and a significant acceleration of the kinetics of the Fc\u2010involved Fenton reaction, collaboratively causing a lipid peroxidation storm in tumor cells. In turn, plenty of lipid peroxides boost PTT through the downregulation of heat shock protein 90. As expected, such a self\u2010cooperative NA demonstrates synergetic tumor eradication in the 4T1 breast tumor\u2010bearing mice xenograft model. This study offers a novel nanotherapeutic paradigm for precise multimodal cancer therapy.<\/jats:p>","DOI":"10.1002\/adhm.202304485","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T06:43:52Z","timestamp":1712126632000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Precisely Self\u2010Cooperative Nanoassembly Enables Photothermal\/Ferroptosis Synergistic Tumor Eradication"],"prefix":"10.1002","volume":"13","author":[{"given":"Xiaohong","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics Wuya College of Innovation Shenyang Pharmaceutical University  Shenyang 110016 P. R. 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